The liver as an endocrine organ—linking NAFLD and insulin resistance

MJ Watt, PM Miotto, W De Nardo… - Endocrine …, 2019 - academic.oup.com
The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …

The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease

N Perakakis, K Stefanakis, CS Mantzoros - Metabolism, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose
spectrum covers clinical, histological and pathophysiological developments ranging from …

Non-invasive diagnosis of non-alcoholic steatohepatitis and fibrosis with the use of omics and supervised learning: a proof of concept study

N Perakakis, SA Polyzos, A Yazdani, A Sala-Vila… - Metabolism, 2019 - Elsevier
Background Non-alcoholic fatty liver disease (NAFLD) affects 25–30% of the general
population and is characterized by the presence of non-alcoholic fatty liver (NAFL) that can …

Liver fat as risk factor of hepatic and cardiometabolic diseases

M Demir, SR Bornstein, CS Mantzoros… - Obesity …, 2023 - Wiley Online Library
Non‐alcoholic fatty liver disease (NAFLD) is a disorder characterized by excessive
accumulation of fat in the liver that can progress to liver inflammation (non‐alcoholic …

Circulating levels of gastrointestinal hormones in response to the most common types of bariatric surgery and predictive value for weight loss over one year: evidence …

N Perakakis, A Kokkinos, N Peradze, N Tentolouris… - Metabolism, 2019 - Elsevier
Aims Bariatric surgery leads to profound and sustainable weight loss. Gastrointestinal
hormones are involved in energy and glucose homeostasis, thus postoperative changes of …

Hepatokines and non-alcoholic fatty liver disease: linking liver pathophysiology to metabolism

TH Kim, DG Hong, YM Yang - Biomedicines, 2021 - mdpi.com
The liver plays a key role in maintaining energy homeostasis by sensing and responding to
changes in nutrient status under various metabolic conditions. Recently highlighted as a …

Remission of type 2 diabetes mellitus after bariatric surgery: fact or fiction?

D Tsilingiris, C Koliaki, A Kokkinos - International journal of environmental …, 2019 - mdpi.com
Although type 2 diabetes mellitus (T2DM) has been traditionally viewed as an intractable
chronic medical condition, accumulating evidence points towards the notion that a complete …

Short-term treatment with high dose liraglutide improves lipid and lipoprotein profile and changes hormonal mediators of lipid metabolism in obese patients with no …

N Peradze, OM Farr, N Perakakis, I Lázaro… - Cardiovascular …, 2019 - Springer
Objective Long-term treatment with up to 1.8 mg liraglutide improves cardiovascular and all-
cause mortality in patients with type 2 diabetes at high risk for cardiovascular disease (CVD) …

Relative Energy Deficiency in sport (REDs): endocrine manifestations, pathophysiology and treatments

AM Angelidi, K Stefanakis, SH Chou… - Endocrine …, 2024 - academic.oup.com
Research on lean, energy-deficient athletic and military cohorts has broadened the concept
of the Female Athlete Triad into the Relative Energy Deficiency in Sport (REDs) syndrome …

Mechanisms of bariatric surgery for weight loss and diabetes remission

M Yin, Y Wang, M Han, R Liang, S Li… - Journal of …, 2023 - Wiley Online Library
Obesity and type 2 diabetes (T2D) lead to defects in intestinal hormones secretion,
abnormalities in the composition of bile acids (BAs), increased systemic and adipose tissue …