Modulating antibody effector functions by Fc glycoengineering

M García-Alija, B Van Moer, DE Sastre, T Azzam… - Biotechnology …, 2023 - Elsevier
Antibody based drugs, including IgG monoclonal antibodies, are an expanding class of
therapeutics widely employed to treat cancer, autoimmune and infectious diseases. IgG …

Bispecific antibody shuttles targeting CD98hc mediate efficient and long-lived brain delivery of IgGs

G Pornnoppadol, LG Bond, MJ Lucas, JM Zupancic… - Cell Chemical …, 2024 - cell.com
The inability of antibodies to penetrate the blood-brain barrier (BBB) is a key limitation to
their use in diverse applications. One promising strategy is to deliver IgGs using a bispecific …

Fluorescence-activated droplet sequencing (FAD-seq) directly provides sequences of screening hits in antibody discovery

A Autour, CA Merten - Proceedings of the National Academy of Sciences, 2024 - pnas.org
Droplet microfluidics has become a very powerful tool in high-throughput screening,
including antibody discovery. Screens are usually carried out by physically sorting droplets …

NAb-seq: an accurate, rapid, and cost-effective method for antibody long-read sequencing in hybridoma cell lines and single B cells

HP Subas Satish, K Zeglinski, RT Uren, SL Nutt… - Mabs, 2022 - Taylor & Francis
Despite their common use in research, monoclonal antibodies are currently not
systematically sequenced. This can lead to issues with reproducibility and the occasional …

Monoclonal Antibodies: Production, Techniques, and Global Marketing

H Yıldız, MT Hüsunet, İH Kenger - Experimental and Applied Medical … - dergipark.org.tr
Monoclonal antibodies are becoming increasingly important for molecular immunology
research. It has also become key components in a wide variety of clinical laboratory …