Hypertrophic cardiomyopathy (HCM) is a genetic disorder that is characterized by left
ventricular hypertrophy unexplained by secondary causes and a nondilated left ventricle …

Hypertrophic cardiomyopathy (HCM) affects more than 1 in 500 people in the general
population with an extensive burden of morbidity in the form of arrhythmia, heart failure, and …

Hypertrophic cardiomyopathy (HCM) is primarily caused by mutations in β-cardiac myosin
and myosin-binding protein-C (MyBP-C). Changes in the contractile parameters of myosin …

The “super-relaxed state”(SRX) of myosin represents a 'reserve'of motors in the heart.
Myosin heads in the SRX are bound to the thick filament and have a very low ATPase rate …

Cardiac myosin binding protein-C (cMyBP-C) is a structural and regulatory component of
cardiac thick filaments. It is observed in electron micrographs as seven to nine transverse …

Mutations in cardiac myosin binding protein C (MyBP-C, encoded by MYBPC3) are the most
common cause of hypertrophic cardiomyopathy (HCM). Most MYBPC3 mutations result in …

Heart failure is highly influenced by heritability, and nearly 100 genes link to familial
cardiomyopathy. Despite the marked genetic diversity that underlies these complex …

We sought to establish a large animal model of inherited hypertrophic cardiomyopathy
(HCM) with sufficient disease severity and early penetrance for identification of novel …

Hypertrophic cardiomyopathy (HCM) is the most prevalent genetically inherited
cardiomyopathy that follows an autosomal dominant inheritance pattern. The majority of …

Hypertrophic cardiomyopathy (HCM) is the most frequently occurring inherited
cardiovascular disease. It is caused by mutations in genes encoding the force-generating …