Abstract Myeloid leukemia 1 (MCL-1) is an antiapoptotic protein of the BCL-2 family that
prevents apoptosis by binding to the pro-apoptotic BCL-2 proteins. Overexpression of MCL …

Acquired resistance to cell death is a hallmark of cancer. The BCL-2 protein family members
play important roles in controlling apoptotic cell death. Abnormal over-expression of pro …

Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is a severe and rapidly evolving epidemic. Now …

Liver cancer is the fourth leading cause of cancer deaths globally, of which hepatocellular
carcinoma (HCC) is the major subtype. Viral hepatitis B and C infections, alcohol abuse, and …

During hypoxic conditions, cells undergo critical adaptive responses that include the up-
regulation of hypoxia-inducible proteins (HIFs) and the induction of the unfolded protein …

Chemoresistance has doubled the effort needed to reach an effective treatment for cancer.
Now, scientists should consider molecular pathways and mechanisms involved in …

Background Sarcopenia is the accelerated loss of muscle mass, strength and function.
Mitochondrial dysfunction was related to the progression of sarcopenia; meanwhile …

Cancer stem cells (CSCs) are a unique population in the tumor, but they only comprise 2%–
5% of the tumor bulk. Although CSCs share several features with embryonic stem cells …

The development of biological technologies in genomics, proteomics, and bioinformatics
has led to the identification and characterization of the complete set of coding genes and …

Pharmacological profile of phytochemicals has attracted much attention to their use in
disease therapy. Since cancer is a major problem for public health with high mortality and …