Statins are widely prescribed cholesterol-lowering drugs that inhibit HMG-CoA reductase
(HMGCR), the rate-limiting enzyme of the mevalonate metabolic pathway. Multiple lines of …

Cancer is a multifaceted global disease. Transformation of a normal to a malignant cell takes
several steps, including somatic mutations, epigenetic alterations, metabolic reprogramming …

Background: Although there are several efficacious vaccines against COVID-19, vaccination
rates in many regions around the world remain insufficient to prevent continued high …

Epithelial ovarian cancer (EOC) is one of the deadliest gynaecological malignancies. The
late diagnosis is frequent due to the absence of specific symptomatology and the molecular …

Background Ovarian cancer remains the most fatal gynecological malignancy. Current
therapeutic options are limited due to late diagnosis in the majority of the cases, metastatic …

The mevalonate pathway provides sterols for membrane structure and nonsterol
intermediates for the post-translational modification and membrane anchorage of growth …

Statins are widely used to treat hypercholesterolaemia. However, by inhibiting the
production of mevalonate, they also reduce the production of several isoprenoids that are …

Objectives: Due to a variety of factors, individuals with diabetes are more likely to develop
anemia. Chronic kidney disease, a frequent consequence of diabetes, is one of the key …

Pancreatic cancer is the seventh leading cause of cancer‐related deaths globally. Metformin
is the standard first‐line of treatment for hyperglycemia in Type 2 diabetes, whereas …

Statins inhibit the synthesis of mevalonate, a precursor isoprenoid molecule to
geranylgeraniol that is necessary for the post‑translational modification of several small …