Atherosclerosis is an inflammatory disease within the arterial wall that is responsible for
several important adverse vascular events, including coronary artery disease, myocardial …

Many drugs that target transforming growth factor-β (TGFβ) signalling have been developed,
some of which have reached Phase III clinical trials for a number of disease applications …

Cancer-associated thrombocytosis has long been linked to poor clinical outcome, but the
underlying mechanism is enigmatic. We hypothesized that platelets promote malignancy …

The focus of this review is to provide an overview of the current state of knowledge of
molecular mechanisms/processes that control differentiation of vascular smooth muscle cells …

PART I THE ENDOTHELIUM has long been viewed as an inert cellophane-like membrane
that lines the circulatory system with its primary essential function being the maintenance of …

Transforming growth factor-β (TGF-β) is a potent regulatory cytokine with diverse effects on
hemopoietic cells. The pivotal function of TGF-β in the immune system is to maintain …

Immune responses participate in every phase of atherosclerosis. There is increasing
evidence that both adaptive and innate immunity tightly regulate atherogenesis. Although …

Atherosclerosis is a chronic disease of the arterial wall where both innate and adaptive
immunoinflammatory mechanisms are involved. Inflammation is central at all stages of …

There is now a large body of evidence suggesting that the decline in ovarian function with
menopause is associated with spontaneous increases in proinflammatory cytokines. The …

Nitric oxide (NO) is a colorless gas at room temperature and one of the simplest molecules
known, yet it has been implicated in a wide variety of regulatory mechanisms ranging from …