Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …

Our efforts to understand the developmental origins of birth defects and disease have
primarily focused on maternal exposures and intrauterine stressors. Recently, research into …

The genome of mammalian sperm is largely packaged by sperm-specific proteins termed
protamines. The presence of some residual nucleosomes has, however, emerged as a …

Mammalian sperm show an unusual and heavily compacted genomic packaging state. In
addition to its role in organizing the compact and hydrodynamic sperm head, it has been …

Hormesis refers to graded adaptive responses to harmful environmental stimuli where low-
level toxicant exposures stimulate tissue growth and responsiveness while, in contrast …

Until recently, clinicians and researchers did not realize paternal exposures could impact
child developmental outcomes. Indeed, although there is growing recognition that sperm …

Increasingly, couples struggling with fertility turn to assisted reproductive techniques,
including IVF, to have children. Despite the demonstrated influence of periconception male …

Background Chronic preconception paternal alcohol use adversely modifies the sperm
epigenome, inducing fetoplacental and craniofacial growth defects in the offspring of …

Paternal health and exposure to adverse environments in the period prior to conception
have a profound impact on future generations. Adversities such as stress, diet, and toxicants …

Multiple lines of evidence suggest that paternal psychological stress contributes to an
increased prevalence of neuropsychiatric and metabolic diseases in the progeny. While …