BDNF therapeutic mechanisms in neuropsychiatric disorders

AH Bazzari, FH Bazzari - International Journal of Molecular Sciences, 2022 - mdpi.com
Brain-derived neurotrophic factor (BDNF) is the most abundant neurotrophin in the adult
brain and functions as both a primary neurotrophic signal and a neuromodulator. It serves …

Epigallocatechin-gallate attenuates rapamycin exacerbated high fat diet-induced autophagy, hormonal dysregulation, testicular and brain oxidative stress, and …

CC Onyekweli, B Ben-Azu, OM Oyovwi… - Food and Chemical …, 2024 - Elsevier
This study investigated whether epigallocatechin-gallate (EGCG) could counteract the
detrimental effects of high-fat diet (HFD)-induced obesity in rats exposed to rapamycin …

[HTML][HTML] Antipsychotic effect of diosgenin in ketamine-induced murine model of schizophrenia: Involvement of oxidative stress and cholinergic transmission

B Ben-Azu, OG Adebayo, AR Fokoua… - IBRO Neuroscience …, 2024 - Elsevier
A decrease in the levels of antioxidant arsenals exacerbate generation of reactive
oxygen/nitrogen species, leading to neurochemical dysfunction, with significant impact on …

Polysaccharide from Flammulina velutipes residues protects mice from Pb poisoning by activating Akt/GSK3β/Nrf-2/HO-1 signaling pathway and modulating gut …

Y Liu, H Li, P Ren, Y Che, J Zhou, W Wang… - International journal of …, 2023 - Elsevier
Lead (Pb) can cause damages to the brain, liver, kidney, endocrine and other systems.
Flammulina velutipes residues polysaccharide (FVRP) has been reported to exhibit anti …

[HTML][HTML] Inhibition of oxido-inflammatory and apoptotic pathway is involved in the protective effect of Ginkgo biloba supplement in cyclosporine-A induced vascular …

JN Asiwe, SI Ovuakporaye, B Ben-Azu… - Pharmacological …, 2023 - Elsevier
Abstract Background Cyclosporine (Cs-A), an immunosuppressant drug used to prevent
organ rejection in patients receiving organ transplants, has been linked to cardiovascular …

[HTML][HTML] Enhancements of Bcl-2/mTOR/ERK1/2 activities by antioxidant mechanisms confer cardioprotection on Ginkgo biloba supplement against isoprenaline …

JN Asiwe, B Ben-Azu, GD Yovwin, SE Ehebha… - Pharmacological …, 2023 - Elsevier
Background Myocyte necrosis and apoptosis can be severely induced by acute adrenergic
stimulation due to the activation of several cell signalling pathways. However, uncertainty …

The protective role of ginsenoside Rg3 in heart diseases and mental disorders

L Shi, J Luo, X Wei, X Xu, L Tu - Frontiers in Pharmacology, 2024 - frontiersin.org
Ginsenoside Rg3, a compound derived from Panax ginseng CA Mey., is increasingly
recognized for its wide range of pharmacological effects. Under the worldwide healthcare …

Sesamin: Insights into its protective effects against lead-induced learning and memory deficits in rats

M Rashno, A Sarkaki, S Ghaderi… - Journal of Trace Elements …, 2022 - Elsevier
Abstract Background Lead (Pb) is one of the most hazardous pollutants that induce a wide
spectrum of neurological changes such as learning and memory deficits. Sesamin, a …

[HTML][HTML] Pleiotropic attenuating effect of Ginkgo biloba against isoprenaline-induced myocardial infarction via improving Bcl-2/mTOR/ERK1/2/Na+, K+-ATPase …

JN Asiwe, AA Ojetola, NE Ekene, E Osirim… - Chinese Herbal …, 2024 - Elsevier
Objective Myocardial infarction (MI) is linked to an imbalance in the supply and demand of
blood oxygen in the heart muscles. Beta-blockers and calcium antagonists are just two of the …

[HTML][HTML] Chronic intermittent oxygen deprivation alters hippocampal cholinergic and glutamatergic system via oxido-inflammatory burden and HIF-1a/Bcl-2 activity in …

OG Adebayo, CI Otene, MU Emmanuel, FC Onwuka… - Phytomedicine Plus, 2023 - Elsevier
Background Several investigations in recent years have reported a relationship between
hypothyroidism or ischemia and central nervous system (CNS) beginning from fetal to adult …