Numerous lines of evidence indicate an association between sustained inflammation and
Parkinson's disease, but whether increased inflammation is a cause or consequence of …

Parkinson's disease (PD) is a progressive and incurable neurodegenerative disorder.
Although numerous genetic and environmental factors have been linked to the aetiology of …

Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20
disease-associated genomic loci. Yet these only explain a small proportion of the genetic …

Neuroinflammation has been implicated in multiple brain disorders but the extent and the
magnitude of change in immune-related genes (IRGs) across distinct brain disorders has not …

Background The molecular drivers of early sporadic Parkinson's disease (PD) remain
unclear, and the presence of widespread end stage pathology in late disease masks the …

The mechanisms responsible for the selective vulnerability of specific neuronal populations
in Parkinson's disease are poorly understood. Oxidative stress secondary to brain iron …

As a means to understand human neuropsychiatric disorders from human brain samples, we
compared the transcription patterns and histological features of postmortem brain to fresh …

Parkinson´ s disease (PD) is a progressive neurodegenerative disorder characterized by
both motor and non-motor symptoms. Aggravation of symptoms is mirrored by accumulation …

The extracellular matrix (ECM) of the brain is a dynamic structure made up of a vast network
of bioactive macromolecules that modulate cellular events. Structural, organizational, and …

Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β plaques and
Tau tangles in brain tissues. Recent studies indicate that aberrant splicing and increased …