The diverse roles of TAO kinases in health and diseases
Thousand and one kinases (TAOKs) are members of the MAP kinase kinase kinase
(MAP3K) family. Three members of this subfamily, TAOK1, 2, and 3, have been identified in …
(MAP3K) family. Three members of this subfamily, TAOK1, 2, and 3, have been identified in …
Genome-wide Mendelian randomization identifies actionable novel drug targets for psychiatric disorders
Psychiatric disorders impose tremendous economic burden on society and are leading
causes of disability worldwide. However, only limited drugs are available for psychiatric …
causes of disability worldwide. However, only limited drugs are available for psychiatric …
Drosophila and Caenorhabditis elegans as Discovery Platforms for Genes Involved in Human Alcohol Use Disorder
M Grotewiel, JC Bettinger - Alcoholism: Clinical and …, 2015 - Wiley Online Library
Background Despite the profound clinical significance and strong heritability of alcohol use
disorder (AUD), we do not yet have a comprehensive understanding of the naturally …
disorder (AUD), we do not yet have a comprehensive understanding of the naturally …
Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood
Childhood obesity is a major public health issue. Here we investigated whether differential
DNA methylation was associated with childhood obesity. We studied DNA methylation …
DNA methylation was associated with childhood obesity. We studied DNA methylation …
Transitional B cells commit to marginal zone B cell fate by Taok3-mediated surface expression of ADAM10
H Hammad, M Vanderkerken, P Pouliot… - Nature …, 2017 - nature.com
Notch2 and B cell antigen receptor (BCR) signaling determine whether transitional B cells
become marginal zone B (MZB) or follicular B (FoB) cells in the spleen, but it is unknown …
become marginal zone B (MZB) or follicular B (FoB) cells in the spleen, but it is unknown …
Rsu1 regulates ethanol consumption in Drosophila and humans
Alcohol abuse is highly prevalent, but little is understood about the molecular causes. Here,
we report that Ras suppressor 1 (Rsu1) affects ethanol consumption in flies and humans …
we report that Ras suppressor 1 (Rsu1) affects ethanol consumption in flies and humans …
The induction of SHP-1 degradation by TAOK3 ensures the responsiveness of T cells to TCR stimulation
A Poirier, JVS Ormonde, I Aubry, BM Abidin… - Science …, 2024 - science.org
Thousand-and-one–amino acid kinase 3 (TAOK3) is a serine and threonine kinase that
belongs to the STE-20 family of kinases. Its absence reduces T cell receptor (TCR) signaling …
belongs to the STE-20 family of kinases. Its absence reduces T cell receptor (TCR) signaling …
The STE20 kinase TAOK3 controls the development of house dust mite–induced asthma in mice
B Maes, U Smole, M Vanderkerken, K Deswarte… - Journal of Allergy and …, 2022 - Elsevier
Background The most common endotype of asthma is type 2–high asthma, which is
sometimes driven by adaptive allergen-specific TH 2 lymphocytes that react to allergens …
sometimes driven by adaptive allergen-specific TH 2 lymphocytes that react to allergens …
Pleiotropic functions of TAO kinases and their dysregulation in neurological disorders
Thousand and one amino acid kinases (TAOKs) are relatively understudied and functionally
pleiotropic protein kinases that have emerged as important regulators of neurodevelopment …
pleiotropic protein kinases that have emerged as important regulators of neurodevelopment …
Conserved Tao kinase activity regulates dendritic arborization, cytoskeletal dynamics, and sensory function in Drosophila
C Hu, AK Kanellopoulos, M Richter… - Journal of …, 2020 - Soc Neuroscience
Dendritic arborization is highly regulated and requires tight control of dendritic growth,
branching, cytoskeletal dynamics, and ion channel expression to ensure proper function …
branching, cytoskeletal dynamics, and ion channel expression to ensure proper function …