[HTML][HTML] Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity

H Yoon, JL Shaw, MC Haigis, A Greka - Molecular cell, 2021 - cell.com
Lipids play crucial roles in signal transduction, contribute to the structural integrity of cellular
membranes, and regulate energy metabolism. Questions remain as to which lipid species …

Ion mobility mass spectrometry in the omics era: Challenges and opportunities for metabolomics and lipidomics

G Paglia, AJ Smith, G Astarita - Mass Spectrometry Reviews, 2022 - Wiley Online Library
Researchers worldwide are taking advantage of novel, commercially available,
technologies, such as ion mobility mass spectrometry (IM‐MS), for metabolomics and …

Deep-profiling of phospholipidome via rapid orthogonal separations and isomer-resolved mass spectrometry

T Xia, F Zhou, D Zhang, X Jin, H Shi, H Yin… - Nature …, 2023 - nature.com
A lipidome comprises thousands of lipid species, many of which are isomers and isobars.
Liquid chromatography-tandem mass spectrometry (LC-MS/MS), although widely used for …

High-end ion mobility mass spectrometry: A current review of analytical capacity in omics applications and structural investigations

DG Delafield, G Lu, CJ Kaminsky, L Li - TrAC Trends in Analytical …, 2022 - Elsevier
Mass spectrometry-based biomolecular analyses have become permanent fixtures of
academic, industrial, and clinical research settings. The rise in utilization of mass …

Advances in high‐throughput mass spectrometry in drug discovery

ME Dueñas, RE Peltier‐Heap, M Leveridge… - EMBO Molecular …, 2023 - embopress.org
High‐throughput (HT) screening drug discovery, during which thousands or millions of
compounds are screened, remains the key methodology for identifying active chemical …

Surface‐assisted laser desorption/ionization mass spectrometry imaging: A review

WH Müller, A Verdin, E De Pauw… - Mass Spectrometry …, 2022 - Wiley Online Library
In the last decades, surface‐assisted laser desorption/ionization mass spectrometry (SALDI‐
MS) has attracted increasing interest due to its unique capabilities, achievable through the …

Nanospray desorption electrospray ionization (Nano-DESI) mass spectrometry imaging with high ion mobility resolution

LX Jiang, E Hernly, H Hu, RT Hilger… - Journal of the …, 2023 - ACS Publications
Untargeted separation of isomeric and isobaric species in mass spectrometry imaging (MSI)
is challenging. The combination of ion mobility spectrometry (IMS) with MSI has emerged as …

High-resolution imaging and identification of biomolecules using Nano-DESI coupled to ion mobility spectrometry

D Unsihuay, R Yin, DM Sanchez, M Yang, Y Li… - Analytica chimica …, 2021 - Elsevier
Simultaneous spatial localization and structural characterization of molecules in complex
biological samples currently represents an analytical challenge for mass spectrometry …

Multimodal imaging based on vibrational spectroscopies and mass spectrometry imaging applied to biological tissue: a multiscale and multiomics review

M Tuck, L Blanc, R Touti, NH Patterson… - Analytical …, 2020 - ACS Publications
Molecular imaging has the potential to unearth important spatial and temporal relationships
in biological systems, including intercellular signaling as well as environmentally-cued …

MS-DIAL 5 multimodal mass spectrometry data mining unveils lipidome complexities

H Takeda, Y Matsuzawa, M Takeuchi… - Nature …, 2024 - nature.com
Lipidomics and metabolomics communities comprise various informatics tools; however,
software programs handling multimodal mass spectrometry (MS) data with structural …