Diabetes mellitus most commonly occurs after the neonatal period and results from complex
interactions between both environmental and incompletely penetrant genetic factors …

Background Beta-cell monogenic forms of diabetes have strong support for precision
medicine. We systematically analyzed evidence for precision treatments for GCK-related …

Aims GCK-MODY leads to mildly elevated blood glucose typically not requiring therapy. It
has been described in all ethnicities, but mainly in Caucasian Europeans. Here we describe …

Neonatal diabetes mellitus (DM) is defined by the onset of persistent hyperglycemia within
the first six months of life but may present up to 12 months of life. A gene mutation affecting …

Ubiquitously expressed throughout the body, ATP-sensitive potassium (KATP) channels
couple cellular metabolism to electrical activity in multiple tissues; their unique assembly as …

Aims/hypothesis Individuals with heterozygous activating mutations of the KCNJ11 gene
encoding a subunit of the ATP-sensitive potassium channel (KATP) can usually be treated …

Diabetes mellitus and impaired fasting glucose associated with single gene mutations are
less rare than previously thought and may account for more than 6% of patients attending a …

Monogenic diabetes is a genetic disorder caused by one or more variations in a single
gene. It encompasses a broad spectrum of heterogeneous conditions, including neonatal …

Neonatal Diabetes (ND) mellitus is a rare genetic disease (1 in 90,000 live births). It is
defined by the presence of severe hyperglycaemia associated with insufficient or no …

Physiologic adaptations in the postnatal period, along with gradual establishment of enteral
feeding, help maintain plasma glucose concentrations in the neonatal period. The definition …