Cerebral oxygen extraction fraction MRI: Techniques and applications

D Jiang, H Lu - Magnetic resonance in medicine, 2022 - Wiley Online Library
The human brain constitutes 2% of the body's total mass but uses 20% of the oxygen. The
rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow …

Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo

PCM van Zijl, K Brindle, H Lu, PB Barker… - Current opinion in …, 2021 - Elsevier
Access to metabolic information in vivo using magnetic resonance (MR) technologies has
generally been the niche of MR spectroscopy (MRS) and spectroscopic imaging (MRSI) …

[HTML][HTML] Hemodynamic and metabolic correspondence of resting-state voxel-based physiological metrics in healthy adults

S Deng, CG Franklin, M O'Boyle, W Zhang, BL Heyl… - Neuroimage, 2022 - Elsevier
Voxel-based physiological (VBP) variables derived from blood oxygen level dependent
(BOLD) fMRI time-course variations include: amplitude of low frequency fluctuations (ALFF) …

Brain oxygen extraction is differentially altered by Alzheimer's and vascular diseases

D Jiang, Z Lin, P Liu, S Sur, C Xu… - Journal of Magnetic …, 2020 - Wiley Online Library
Background Alzheimer's disease and vascular cognitive impairment (VCI), as well as their
concurrence, represent the most common types of cognitive dysfunction. Treatment …

[HTML][HTML] Evaluation of whole-brain oxygen metabolism in Alzheimer's disease using QSM and quantitative BOLD

A Yang, H Zhuang, L Du, B Liu, K Lv, J Luan, P Hu… - NeuroImage, 2023 - Elsevier
Objective The objective of this study was to evaluate the whole-brain pattern of oxygen
extraction fraction (OEF), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen …

[HTML][HTML] MRI assessment of cerebral oxygen extraction fraction in the medial temporal lobe

D Jiang, P Liu, Z Lin, K Hazel, G Pottanat, E Lucke… - NeuroImage, 2023 - Elsevier
The medial temporal lobe (MTL) is a key area implicated in many brain diseases, such as
Alzheimer's disease. As a functional biomarker, the oxygen extraction fraction (OEF) of MTL …

QQ‐NET–using deep learning to solve quantitative susceptibility mapping and quantitative blood oxygen level dependent magnitude (QSM+ qBOLD or QQ) based …

J Cho, J Zhang, P Spincemaille… - Magnetic resonance …, 2022 - Wiley Online Library
Purpose To improve accuracy and speed of quantitative susceptibility mapping plus
quantitative blood oxygen level‐dependent magnitude (QSM+ qBOLD or QQ)‐based …

Temporal clustering, tissue composition, and total variation for mapping oxygen extraction fraction using QSM and quantitative BOLD

J Cho, P Spincemaille, TD Nguyen… - Magnetic resonance …, 2021 - Wiley Online Library
Purpose To improve the accuracy of quantitative susceptibility mapping plus quantitative
blood oxygen level‐dependent magnitude (QSM+ qBOLD or QQ) based mapping of oxygen …

A noninvasive method for quantifying cerebral metabolic rate of oxygen by hybrid PET/MRI: validation in a porcine model

L Narciso, T Ssali, L Liu, H Biernaski… - Journal of Nuclear …, 2021 - Soc Nuclear Med
The gold standard for imaging the cerebral metabolic rate of oxygen (CMRO2) is PET;
however, it is an invasive and complex procedure that also requires correction for …

Multi‐parametric evaluation of cerebral hemodynamics in neonatal piglets using non‐contrast‐enhanced magnetic resonance imaging methods

D Liu, D Jiang, A Tekes, E Kulikowicz… - Journal of Magnetic …, 2021 - Wiley Online Library
Background Disruption of brain oxygen delivery and consumption after hypoxic–ischemic
injury contributes to neonatal mortality and neurological impairment. Measuring cerebral …