Gene therapy targeting p53 and KRAS for colorectal cancer treatment: a myth or the way forward?

HH Hasbullah, M Musa - International journal of molecular sciences, 2021 - mdpi.com
Colorectal cancer (CRC) is the third most commonly diagnosed malignancy worldwide and
is responsible as one of the main causes of mortality in both men and women. Despite …

Molecular targeted drugs and treatment of colorectal cancer: recent progress and future perspectives

F Geng, Z Wang, H Yin, J Yu, B Cao - Cancer biotherapy & …, 2017 - liebertpub.com
Nowadays, colorectal cancer is the fourth most common type of tumor all over the world.
When diagnosed,∼ 50%–60% of tumors have metastasized, thus resulting in a grim …

[HTML][HTML] CircBACH1/let-7a-5p axis enhances the proliferation and metastasis of colorectal cancer by upregulating CREB5 expression

J Li, Q Tang, W Dong, Y Wang - Journal of Gastrointestinal …, 2020 - ncbi.nlm.nih.gov
Background In this study, we investigated the influences of circBACH1 on the proliferation,
metastasis, migration, and apoptosis of human colorectal cancer LoVo cells and explored …

Development of a semiconductor sequencing-based panel for screening individuals with Lynch syndrome

RIM Yunos, NS Ab Mutalib… - … In Microbes & …, 2022 - journals.hh-publisher.com
Development of a Semiconductor Sequencing-based Panel for Screening Individuals with
Lynch Syndrome Page 1 PMMB 2022, 5, 1; a0000274. doi: 10.36877/pmmb.a0000274 http://journals.hh-publisher.com/index.php/pmmb …

[PDF][PDF] A review of colorectal cancer research in Malaysia

LK Ghee - Med J Malaysia, 2014 - Citeseer
SUMMARY 105 articles related to colorectal cancer (CRC) were found in a search through a
database dedicated to indexing all original data relevant to medicine published in Malaysia …

KRAS Mutational Profiles among Colorectal Cancer Patients in the East Coast of Peninsular Malaysia

HH Hasbullah, S Sulong, NA Che Jalil, AA Abdul Aziz… - Diagnostics, 2023 - mdpi.com
Background: KRAS is a key driver gene in colorectal carcinogenesis. Despite this, there are
still limited data on the mutational status of KRAS amongst colorectal cancer (CRC) patients …

[PDF][PDF] Significance of DNA mismatch repair genes and microsatellite instability in colorectal carcinoma in Ibadan, Nigeria

BM Duduyemi, EEU Akang, PA Adegboyega… - Am J Med Biol …, 2013 - researchgate.net
Background: Though the incidence of colorectal carcinoma (CRC) is relatively uncommon in
Nigeria, compared to the developed countries, recent studies indicate an increasing trend …

[HTML][HTML] Comparison of K-ras mutations in lung, colorectal and gastric cancer

N Peng, X Zhao - Oncology letters, 2014 - spandidos-publications.com
K-ras is involved in the EGFR pathway that regulates cell survival, motility and proliferation,
as well as angiogenesis and metastasis. It is also essential for carcinogenesis. The K-ras …

Genomic and epigenetic instability in colorectal cancer

A Safaei, S Sobhi, MR Tavirani… - International Journal of …, 2013 - brieflands.com
: Colorectal Cancer (CRC) is the third most common cancer in men and the second most
common cancer in women worldwide. Both genetic and epigenetic alterations are common …

[PDF][PDF] Identifying common mutations in colorectal cancer using a 7-gene panel by next generation sequencing

CB Lee, YW Kien, N Dusa… - Malays. J. Med …, 2019 - medic.upm.edu.my
Introduction: Colorectal cancer (CRC) arises from the cumulative effects of genetic and
epigenetic alterations. Current treatment of metastatic CRC relies on combination of …