Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Advances over the past 25 years have revealed much about how the structural properties of
membranes and associated proteins are linked to the thermodynamics and kinetics of …

The human voltage-sensitive K+ channel hERG plays a fundamental role in cardiac action
potential repolarization, effectively controlling the QT interval of the electrocardiogram …

Electrical signaling was a dramatic development in evolution, allowing complex single-cell
organisms like Paramecium to coordinate movement and early metazoans like worms and …

Quaternary ammonium blockers were previously shown to bind in the pore to block both
open and closed conformations of large-conductance calcium-activated potassium (BK and …

Voltage-gated sodium channels (Nav) underlie the electrical activity of nerve and muscle
cells. Humans have nine different subtypes of these channels, which are the target of small …

Voltage‐gated ion channels are transmembrane proteins responsible for the generation and
propagation of action potentials in excitable cells. Over the last decade, advancements have …

TWIK-related acid-sensitive K+ (TASK) channels, including TASK-1, TASK-3, and TASK-5,
are important members of the two-pore domain potassium (K2P) channel family. TASK-5 is …

Biological membranes and their diverse lipid constituents play key roles in a broad spectrum
of cellular and physiological processes. Characterization of membrane-associated …

Two-pore-domain potassium (K2P) channels are key regulators of many physiological and
pathophysiological processes and thus emerged as promising drug targets. As for other …