Bioresponsive polymers have been widely used in drug delivery because of their
degradability. For example, poly (disulfide) s with repeating disulfide bonds in the main …

In cancer, much uncertainty remains regarding the origins of metastatic disease. Models of
metastatic progression offer competing views on when dissemination occurs (at an early or …

The spread of cancer cells from primary tumors to regional lymph nodes is often associated
with reduced survival. One prevailing model to explain this association posits that fatal …

A major unanswered question in neuroscience is whether there exists genomic variability
between individual neurons of the brain, contributing to functional diversity or to an …

Human cancers display substantial intratumoral genetic heterogeneity, which facilitates
tumor survival under changing microenvironmental conditions. Tumor substructure and its …

Stem cell dynamics in vivo are often being studied by lineage tracing methods. Our
laboratory has previously developed a retrospective method for reconstructing cell lineage …

Because mutations are inevitable, the genome of each cell in a multicellular organism
becomes unique and therefore encodes a record of its ancestry. Here we coupled arbitrary …

Fundamental aspects of embryonic and post-natal development, including maintenance of
the mammalian female germline, are largely unknown. Here we employ a retrospective …

Chronic inflammation predisposes to a variety of human cancers. Affected tissues slowly
accumulate mutations, some of which affect growth regulation and drive successive waves …

Abstract Almost 50 years ago, Earl Benditt and his son John described the clonality of the
atherosclerotic plaque. This led Benditt to propose that the atherosclerotic lesion was a …