Translational research in vitiligo

EL Katz, JE Harris - Frontiers in immunology, 2021 - frontiersin.org
Vitiligo is a disease of the skin characterized by the appearance of white spots. Significant
progress has been made in understanding vitiligo pathogenesis over the past 30 years, but …

Vitiligo: pathogenetic hypotheses and targets for current therapies

L Guerra, E Dellambra, S Brescia… - Current drug …, 2010 - ingentaconnect.com
Vitiligo is a multifactorial disorder characterized by the appearance of white maculae that
may spread over the entire body skin. Depigmentation arises from the loss of functioning …

Suction blistering the lesional skin of vitiligo patients reveals useful biomarkers of disease activity

JP Strassner, M Rashighi, MA Refat… - Journal of the American …, 2017 - Elsevier
Background Vitiligo is an autoimmune disease of the skin with limited treatment options;
there is an urgent need to identify and validate biomarkers of disease activity to support …

Diagnostic opportunities based on skin biomarkers

S Paliwal, BH Hwang, KY Tsai, S Mitragotri - European journal of …, 2013 - Elsevier
Systemic as well as localized skin diseases modify the molecular composition of human
skin. Changes in skin chemistry have been observed in diseases such as cancer, psoriasis …

T‐cell positioning by chemokines in autoimmune skin diseases

JM Richmond, JP Strassner, KI Essien… - Immunological …, 2019 - Wiley Online Library
Autoimmune skin diseases are complex processes in which autoreactive cells must navigate
through the skin tissue to find their targets. Regulatory T cells in the skin help to mitigate …

Basic fibroblast growth factor promotes melanocyte migration via activating PI3K/Akt‐Rac1‐FAK‐JNK and ERK signaling pathways

H Shi, B Lin, Y Huang, J Wu, H Zhang, C Lin… - IUBMB …, 2016 - Wiley Online Library
Vitiligo is a depigmentation disorder characterized by loss of functional melanocytes of the
skin epidermis. The pathogenesis of vitiligo remains elusive. The purpose of this study is to …

Basic fibroblast growth factor and tumour necrosis factor alpha in vitiligo and other hypopigmented disorders: suggestive possible therapeutic targets

H Seif El Nasr, OG Shaker, MMT Fawzi… - Journal of the …, 2013 - Wiley Online Library
Background In healthy skin, there is a molecular microenvironment that favours the survival
of melanocytes and regulates their function. Keratinocytes synthesize and secrete several …

The changes of gene expression profiling between segmental vitiligo, generalized vitiligo and healthy individual

P Wang, Y Li, H Nie, X Zhang, Q Shao, X Hou… - Journal of …, 2016 - Elsevier
Background Vitiligo is a common acquired depigmentation skin disease characterized by
loss or dysfunction of melanocytes within the skin lesion, but its pathologenesis is far from …

Treatments of vitiligo: what's new at the horizon

TM Lotti, J Hercogová, RA Schwartz… - Dermatologic …, 2012 - Wiley Online Library
Vitiligo is a manageable disease. However, current vitiligo treatments can be considered
suboptimal as they do not guarantee high efficacy and cannot be standardized for most …

[PDF][PDF] 白瘾风表皮微环境研究进展

陈惠英, 许爱域 - Chin J Derm Venereol, 2008 - mediskin.cn
CHEN Hui-ying, XUA-ie 白疯风是一种由于黑素细胞受损而致色素脱失的获得性皮肤病,
其病因及发病机制迄今尚未完全阐明, 本文着重从皮损处存在氧化应激, 神经, 免疫 …