Proliferative vitreoretinopathy: a review

S Idrees, J Sridhar, AE Kuriyan - International ophthalmology …, 2019 - journals.lww.com
Proliferative vitreoretinopathy (PVR) is the most common cause for failure of
rhegmatogenous retinal detachment repair and is characterized by the growth and …

Proliferative vitreoretinopathy: a new concept of disease pathogenesis and practical consequences

JC Pastor, J Rojas, S Pastor-Idoate, S Di Lauro… - Progress in retinal and …, 2016 - Elsevier
During the last four decades, proliferative vitreoretinopathy (PVR) has defied the efforts of
many researchers to prevent its occurrence or development. Thus, PVR is still the major …

PDGFs and their receptors

A Kazlauskas - Gene, 2017 - Elsevier
The platelet-derived growth factor (PDGF)/PDGFR receptor (PDGFR) family is essential for a
vast array of physiological processes such as migration and proliferation of percityes that …

Is neutralizing vitreal growth factors a viable strategy to prevent proliferative vitreoretinopathy?

S Pennock, LJ Haddock, D Eliott, S Mukai… - Progress in retinal and …, 2014 - Elsevier
Proliferative vitreoretinopathy (PVR) is a blinding disorder that occurs in eyes with
rhegmatogenous retinal detachment and in eyes that have recently undergone retinal …

Proliferative vitreoretinopathy: a reappraisal

P Carpineto, AM Licata, M Ciancaglini - Journal of Clinical Medicine, 2023 - mdpi.com
Proliferative vitreoretinopathy (PVR) remains the main cause of failure after retinal
detachment (RD) surgery. Despite the development of modern technologies and …

The roles of mouse double minute 2 (MDM2) oncoprotein in ocular diseases: A review

H Jiang, J Luo, H Lei - Experimental Eye Research, 2022 - Elsevier
Abstract Mouse double minute 2 (MDM2), an E3 ubiquitin ligase and the primary negative
regulator of the tumor suppressor p53, cooperates with its structural homolog MDM4/MDMX …

Molecular targets for proliferative vitreoretinopathy

F Wu, D Eliott - Seminars in ophthalmology, 2021 - Taylor & Francis
While innovations in the surgical management of retinal detachment (RD) with proliferative
vitreoretinopathy (PVR) have significantly improved anatomic and visual outcomes over the …

[HTML][HTML] Vascular endothelial growth factor acts primarily via platelet-derived growth factor receptor α to promote proliferative vitreoretinopathy

S Pennock, LJ Haddock, S Mukai… - The American journal of …, 2014 - Elsevier
Proliferative vitreoretinopathy (PVR) is a nonneovascular blinding disease and the leading
cause for failure in surgical repair of rhegmatogenous retinal detachments. Once formed …

Progress in the application of CRISPR: from gene to base editing

W Wu, Y Yang, H Lei - Medicinal Research Reviews, 2019 - Wiley Online Library
The system of clustered regularly interspaced short palindromic repeats (CRISPR) and
CRISPR‐associated endonucleases (Cas) has been utilized for genome editing with great …

Phosphoinositide 3-kinase δ inactivation prevents vitreous-induced activation of AKT/MDM2/p53 and migration of retinal pigment epithelial cells

H Han, N Chen, X Huang, B Liu, J Tian, H Lei - Journal of Biological …, 2019 - ASBMB
Phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases that play a critical role in
transmitting signals from cell-surface molecules to intracellular protein effectors. Key PI3Ks …