Targeting apoptosis in cancer
P Singh, B Lim - Current oncology reports, 2022 - Springer
Abstract Purpose of Review Apoptosis is a major mechanism of cancer cell death. Thus,
evasion of apoptosis results in therapy resistance. Here, we review apoptosis modulators in …
evasion of apoptosis results in therapy resistance. Here, we review apoptosis modulators in …
Regulation of the master regulator FOXM1 in cancer
GB Liao, XZ Li, S Zeng, C Liu, SM Yang, L Yang… - Cell Communication and …, 2018 - Springer
FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor
that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the …
that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the …
m6A demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation program
The dynamic and reversible N 6-methyladenosine (m 6 A) RNA modification installed and
erased by N 6-methyltransferases and demethylases regulates gene expression and cell …
erased by N 6-methyltransferases and demethylases regulates gene expression and cell …
Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy
Cancer stem cells are critical for cancer initiation, development, and treatment resistance.
Our understanding of these processes, and how they relate to glioblastoma heterogeneity, is …
Our understanding of these processes, and how they relate to glioblastoma heterogeneity, is …
Human embryonic genome activation initiates at the one-cell stage
In human embryos, the initiation of transcription (embryonic genome activation [EGA]) occurs
by the eight-cell stage, but its exact timing and profile are unclear. To address this, we …
by the eight-cell stage, but its exact timing and profile are unclear. To address this, we …
[HTML][HTML] Dysregulated FOXM1 signaling in the regulation of cancer stem cells
Since the introduction of the cancer stem cell (CSC) paradigm, significant advances have
been made in understanding the functional and biological plasticity of these elusive …
been made in understanding the functional and biological plasticity of these elusive …
FOXM1 and cancer: faulty cellular signaling derails homeostasis
D Kalathil, S John, AS Nair - Frontiers in oncology, 2021 - frontiersin.org
Forkhead box transcription factor, FOXM1 is implicated in several cellular processes such as
proliferation, cell cycle progression, cell differentiation, DNA damage repair, tissue …
proliferation, cell cycle progression, cell differentiation, DNA damage repair, tissue …
Cancer stem cells in glioblastoma
Tissues with defined cellular hierarchies in development and homeostasis give rise to
tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and …
tumors with cellular hierarchies, suggesting that tumors recapitulate specific tissues and …
Glioma-initiating cells at tumor edge gain signals from tumor core cells to promote their malignancy
Intratumor spatial heterogeneity facilitates therapeutic resistance in glioblastoma (GBM).
Nonetheless, understanding of GBM heterogeneity is largely limited to the surgically …
Nonetheless, understanding of GBM heterogeneity is largely limited to the surgically …
Preferential iron trafficking characterizes glioblastoma stem-like cells
Glioblastomas display hierarchies with self-renewing cancer stem-like cells (CSCs). RNA
sequencing and enhancer mapping revealed regulatory programs unique to CSCs causing …
sequencing and enhancer mapping revealed regulatory programs unique to CSCs causing …