Molecular mechanisms of MmuPV1 E6 and E7 and implications for human disease

JC Romero-Masters, PF Lambert, K Munger - Viruses, 2022 - mdpi.com
Human papillomaviruses (HPVs) cause a substantial amount of human disease from benign
disease such as warts to malignant cancers including cervical carcinoma, head and neck …

WHIM syndrome: Immunopathogenesis, treatment and cure strategies

DH McDermott, PM Murphy - Immunological reviews, 2019 - Wiley Online Library
WHIM syndrome is a rare, autosomal dominant immunodeficiency which is named for the
four key manifestations: Warts, Hypogammaglobulinemia, Infections, and Myelokathexis. It …

A Novel In Vivo Infection Model To Study Papillomavirus-Mediated Disease of the Female Reproductive Tract

ME Spurgeon, A Uberoi, SM McGregor, T Wei… - MBio, 2019 - Am Soc Microbiol
Papillomaviruses exhibit species-specific tropism, thereby limiting understanding and
research of several aspects of HPV infection and carcinogenesis. The discovery of a murine …

CXCR4 signaling controls dendritic cell location and activation at steady state and in inflammation

C Gallego, M Vétillard, J Calmette… - Blood, The Journal …, 2021 - ashpublications.org
Dendritic cells (DCs) encompass several cell subsets that collaborate to initiate and regulate
immune responses. Proper DC localization determines their function and requires the tightly …

An infection-based murine model for papillomavirus-associated head and neck cancer

T Wei, D Buehler, E Ward-Shaw, PF Lambert - MBio, 2020 - Am Soc Microbiol
Human papillomavirus (HPV) is the most common sexually transmitted pathogen, and high-
risk HPVs contribute to 5% of human cancers, including 25% of head and neck squamous …

A novel model for papillomavirus-mediated anal disease and cancer using the mouse papillomavirus

S Blaine-Sauer, MK Shin, KA Matkowskyj… - Mbio, 2021 - Am Soc Microbiol
Up to 95% of all anal cancers are associated with infection by human papillomavirus (HPV);
however, no established preclinical model exists for high-grade anal disease and cancer …

MmuPV1 E7's interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease

JC Romero-Masters, M Grace, D Lee, J Lei… - PLoS …, 2023 - journals.plos.org
Human papillomaviruses (HPVs) contribute to approximately 5% of all human cancers.
Species-specific barriers limit the ability to study HPV pathogenesis in animal models …

A Novel In Vivo Model of Laryngeal Papillomavirus-Associated Disease Using Mus musculus Papillomavirus

RE King, A Bilger, J Rademacher, ET Ward-Shaw… - Viruses, 2022 - mdpi.com
Recurrent respiratory papillomatosis (RRP), caused by laryngeal infection with low-risk
human papillomaviruses, has devastating effects on vocal communication and quality of life …

MmuPV1 E6 induces cell proliferation and other hallmarks of cancer

JC Romero-Masters, LK Muehlbauer, M Hayes… - Mbio, 2023 - Am Soc Microbiol
The E6 protein encoded by the murine papillomavirus (MmuPV1) is essential for MmuPV1-
induced skin disease. Our previous work has identified a number of cellular interacting …

Increased Susceptibility of WHIM Mice to Papillomavirus-induced Disease is Dependent upon Immune Cell Dysfunction

W Wang, A Pope, E Ward-Shaw, D Buehler… - PLoS …, 2024 - journals.plos.org
Warts, Hypogammaglobulinemia, Infections, and Myelokathexis (WHIM) syndrome is a rare
primary immunodeficiency disease in humans caused by a gain of function in CXCR4 …