Gene therapy for neurological disorders has attracted significant interest as a way to reverse
or stop various disease pathologies. Typical gene therapies involving the central and …

Cancer is a worldwide health problem. Personalized treatment represents a future
advancement for cancer treatment, in part due to the development of targeted therapeutic …

The progressive degeneration of the dopamine neurons of the pars compacta of substantia
nigra and the consequent loss of the dopamine innervation of the striatum leads to the …

Background The anti-inflammatory effect of the cerebral dopamine neurotrophic factor
(CDNF) was shown recently in primary glial cell cultures, yet such effect remains unknown …

Abstract Background The neurotrophin Brain-Derived Neurotrophic Factor (BDNF)
influences nigral dopaminergic neurons via autocrine and paracrine mechanisms. The …

Background The development of minimally invasive, non‐viral gene delivery vehicles for the
central nervous system (CNS) is an important technology goal in the advancement of …

Recently we showed that the neurotensin polyplex is a nanoparticle carrier system that
targets reporter genes in nigral dopamine neurons in vivo. Herein, we report its first practical …

Nanomedicine has focused on targeted neurotrophic gene delivery to the brain as a strategy
to stop and reverse neurodegeneration in Parkinson's disease. Because of improved …

Parkinsonism by unilateral, intranigral β-sitosterol β-D-glucoside administration in rats is
distinguished in that the α-synuclein insult begins unilaterally but spreads bilaterally and …

In the past few years gene delivery system has gained a huge attention owing to its proved
efficacy in several diseases especially in those caused by genetic and/or oncological …