Genetic variation and adaptation in Africa: implications for human evolution and disease

F Gomez, J Hirbo, SA Tishkoff - Cold Spring Harbor …, 2014 - cshperspectives.cshlp.org
Because modern humans originated in Africa and have adapted to diverse environments,
African populations have high levels of genetic and phenotypic diversity. Thus, genomic …

Oldies but Goldies mtDNA Population Variants and Neurodegenerative Diseases

PF Chinnery, A Gomez-Duran - Frontiers in neuroscience, 2018 - frontiersin.org
mtDNA is transmitted through the maternal line and its sequence variability, which is
population specific, is assumed to be phenotypically neutral. However, several studies have …

The first modern human dispersals across Africa

T Rito, MB Richards, V Fernandes, F Alshamali… - PloS one, 2013 - journals.plos.org
The emergence of more refined chronologies for climate change and archaeology in
prehistoric Africa, and for the evolution of human mitochondrial DNA (mtDNA), now make it …

Recent historical migrations have shaped the gene pool of Arabs and Berbers in North Africa

LR Arauna, J Mendoza-Revilla… - Molecular biology …, 2016 - academic.oup.com
North Africa is characterized by its diverse cultural and linguistic groups and its genetic
heterogeneity. Genomic data has shown an amalgam of components mixed since pre …

A survey of sub-Saharan gene flow into the Mediterranean at risk loci for coronary artery disease

MM Álvarez-Álvarez, D Zanetti… - European Journal of …, 2017 - nature.com
This study tries to find detectable signals of gene flow of Sub-Saharan origin into the
Mediterranean in four genomic regions previously associated with coronary artery disease …

The history of the North African mitochondrial DNA haplogroup U6 gene flow into the African, Eurasian and American continents

B Secher, R Fregel, JM Larruga, VM Cabrera… - BMC evolutionary …, 2014 - Springer
Abstract Background Complete mitochondrial DNA (mtDNA) genome analyses have greatly
improved the phylogeny and phylogeography of human mtDNA. Human mitochondrial DNA …

Convex clustering: An attractive alternative to hierarchical clustering

GK Chen, EC Chi, JMO Ranola… - PLoS computational …, 2015 - journals.plos.org
The primary goal in cluster analysis is to discover natural groupings of objects. The field of
cluster analysis is crowded with diverse methods that make special assumptions about data …

In search of the genetic footprints of Sumerians: a survey of Y-chromosome and mtDNA variation in the Marsh Arabs of Iraq

N Al-Zahery, M Pala, V Battaglia, V Grugni… - BMC evolutionary …, 2011 - Springer
Background For millennia, the southern part of the Mesopotamia has been a wetland region
generated by the Tigris and Euphrates rivers before flowing into the Gulf. This area has been …

Population expansion in the North African late Pleistocene signalled by mitochondrial DNA haplogroup U6

L Pereira, NM Silva, R Franco-Duarte… - BMC evolutionary …, 2010 - Springer
Abstract Background The archaeology of North Africa remains enigmatic, with questions of
population continuity versus discontinuity taking centre-stage. Debates have focused on …

Introducing the Algerian mitochondrial DNA and Y-chromosome profiles into the North African landscape

A Bekada, R Fregel, VM Cabrera, JM Larruga… - PLoS …, 2013 - journals.plos.org
North Africa is considered a distinct geographic and ethnic entity within Africa. Although
modern humans originated in this Continent, studies of mitochondrial DNA (mtDNA) and Y …