Introduction Thymic stromal lymphopoietin (TSLP), an epithelial cytokine (alarmin), is a
central regulator of the immune response to inhaled environmental insults such as …

Basophils were discovered by Paul Ehrlich in 1879 and represent the least abundant
granulocyte population in mammals. The relative rarity of basophils and their phenotypic …

Background Tezepelumab is a human monoclonal antibody that blocks the activity of thymic
stromal lymphopoietin (TSLP), an epithelial cell-derived cytokine. In phase 2b and 3 studies …

Asthma is a common heterogeneous disease with a complex pathophysiology. Current
therapies based on inhaled corticosteroids and longacting β 2 agonists are effective in …

Highlights•The triad of cytokines, IL-25, IL-33 and TSLP, play a defined role in allergic
inflammation at mucosal surfaces.•The precise function of these cytokines during human …

Asthma is a chronic disease related to airway hyperresponsiveness and airway remodeling.
Airway remodeling is the important reason of refractory asthma and is associated with …

Despite treatment with standard-of-care medications, including currently available biologic
therapies, many patients with severe asthma have uncontrolled disease, which is associated …

Airway remodeling is accepted to be a determining component within the natural history of
asthma. It is a phenomenon characterized by changes in the airways structures that marches …

Asthma is a heterogeneous disease commonly driven by allergic and/or eosinophilic
inflammation, both of which may be present in severe disease. Most approved biologics for …

Cellular senescence is a complicated process featured by irreversible cell cycle arrest and
senescence-associated secreted phenotype (SASP), resulting in accumulation of senescent …