Objectives: To review mechanisms underlying sepsis-induced cardiac dysfunction in
general and intrinsic myocardial depression in particular. Data Source: MEDLINE database …

Sex and gender dimorphisms are found in a large variety of diseases, including sepsis and
septic shock which are more prevalent in men than in women. Animal models show that the …

Hypoxia-inducible factor 1α (HIF-1α) and HIF-2α display unique and sometimes opposing
activities in regulating cellular energy homeostasis, cell fate decisions, and oncogenesis …

Objective: To investigate the impact of circulating histones on cardiac injury and dysfunction
in a murine model and patients with sepsis. Design: Prospective, observational clinical study …

Septic shock is characterized by circulatory compromise, microcirculatory alterations and
mitochondrial damage, which all reduce cellular energy production. In order to reduce the …

Cardiac dysfunction is a well-recognized complication of severe sepsis and septic shock.
Cardiac dysfunction in sepsis is characterized by ventricular dilatation, reduction in ejection …

Defective cardiac function during sepsis has been referred to as “cardiomyopathy of sepsis.”
It is known that sepsis leads to intensive activation of the complement system. In the current …

The existence of an inducible mitochondrial nitric oxide synthase has been recently related
to the nitrosative/oxidative damage and mitochondrial dysfunction that occurs during …

Abstract Hemorrhage, trauma, ischemia/reperfusion, burn, and sepsis each lead to cardiac
dysfunction. These insults lead to an inflammatory cascade, which plays an important role in …

Nitric Oxide (NO) plays a controversial role in the pathophysiology of sepsis and septic
shock. Its vasodilatory effects are well known, but it also has pro-and antiinflammatory …