Mediators of chronic pruritus in atopic dermatitis: getting the itch out?

NK Mollanazar, PK Smith, G Yosipovitch - Clinical reviews in allergy & …, 2016 - Springer
For centuries, itch was categorized as a submodality of pain. Recent research over the last
decade has led to the realization that itch is in fact a separate and distinct, albeit closely …

Neuro-immune interactions in allergic diseases: novel targets for therapeutics

T Voisin, A Bouvier, IM Chiu - International Immunology, 2017 - academic.oup.com
Recent studies have highlighted an emerging role for neuro-immune interactions in
mediating allergic diseases. Allergies are caused by an overactive immune response to a …

Atopic dermatitis yardstick: practical recommendations for an evolving therapeutic landscape

M Boguniewicz, L Fonacier, E Guttman-Yassky… - Annals of Allergy …, 2018 - Elsevier
The implementation of treatment guidelines for atopic dermatitis is challenging, in part
because of different guidance documents being used by different groups of specialists and …

[HTML][HTML] Mechanistic insights into the antipruritic effects of lebrikizumab, an anti–IL-13 mAb

Y Miron, PE Miller, C Hughes, T Indersmitten… - Journal of Allergy and …, 2022 - Elsevier
Background Atopic dermatitis (AD) is a chronic, inflammatory skin disease with persistent
and severe itch among its hallmark features. Significant increases in type 2 cytokines (ie, IL …

Management of itch in atopic dermatitis

J Pavlis, G Yosipovitch - American journal of clinical dermatology, 2018 - Springer
Atopic dermatitis (AD) is the most common itchy dermatosis that affects millions of children
and adults worldwide. Chronic itch in this condition has significant impact on measures of …

[HTML][HTML] Trends in atopic dermatitis—from standard pharmacotherapy to novel drug delivery systems

EB Souto, J Dias-Ferreira, J Oliveira… - International journal of …, 2019 - mdpi.com
Atopic dermatitis (AD) is a predominant and deteriorating chronic inflammation of the skin,
categorized by robust burning and eczematous lacerations in diverse portions of the body …

The Role of Immune Defects and Colonization of Staphylococcus aureus in the Pathogenesis of Atopic Dermatitis

D Nowicka, E Grywalska - Analytical Cellular Pathology, 2018 - Wiley Online Library
Atopic dermatitis (AD) is a condition with a complex and not fully understood etiology. In
patients with AD, acute skin lesions are colonized by a greater number of Staphylococcus …

[HTML][HTML] Fc Epsilon RI–Neuroimmune Interplay in Pruritus Triggered by Particulate Matter in Atopic Dermatitis Patients

D Isaifan, S Crovella, L Soubra, M Al-Nesf… - International Journal of …, 2023 - mdpi.com
Atopic dermatitis (AD) is the most common chronic relapsing neuroinflammatory skin
disease that is characterized by a complex and multifactorial pathophysiology. It reflects a …

Characteristics of pruritus in relation to self-assessed severity of atopic dermatitis

F Huet, MS Faffa, F Poizeau… - Acta Dermato …, 2019 - univ-rennes.hal.science
The objective of this study was to explore characteristics of pruritus in atopic dermatitis (AD)
in relation to the severity of AD. A web-questionnaire was used, which included the Patient …

Phloretin‐induced cytoprotective effects on mammalian cells: A mechanistic view and future directions

MR de Oliveira - Biofactors, 2016 - Wiley Online Library
Abstract Phloretin (C15H14O5), a dihydrochalcone flavonoid, is mainly found in fruit, leaves,
and roots of apple tree. Phloretin exerts antioxidant, anti‐inflammatory, and anti‐tumor …