Objective Critical limb ischemia (CLI) is associated with high morbidity and mortality.
Because most patients with CLI will eventually undergo some type of revascularization, the …

Critical limb ischemia (CLI), the most severe form of peripheral artery disease, is
characterized by pain at rest and non-healing ulcers in the lower extremities. For patients …

Background: Treatment of critical limb ischemia (CLI) by bypass operation or percutaneous
vascular intervention is occasionally difficult. The safety and efficacy of multiple …

After the onset of ischemia, cardiac or skeletal muscle undergoes a continuum of molecular,
cellular, and extracellular responses that determine the function and the remodeling of the …

Background Peripheral vascular disease of the lower extremities comprises a clinical
spectrum that extends from no symptoms to presentation with critical limb ischemia (CLI) …

The age-adjusted prevalence of peripheral arterial disease in the US population was
estimated to approach 12% in 1985, and as the population ages, the overall population …

Bioengineering strategies to enhance the natural targeting function of nanocarriers would
expand their therapeutic applications. Here, we designed bioengineered stem cell …

Background Stem cells are a unique cell population characterized by self-renewal and
cellular differentiation capabilities. These characteristics, among other traits, make them an …

Background: Critical Limb Ischemia (CLI) is the most advanced stage of peripheral arterial
disease and is usually treated with bypass surgery or endovascular revascularization …

Critical limb ischemia (CLI) due to Buerger's disease is a major unmet medical need with a
high incidence of morbidity. This phase II, prospective, nonrandomized, open-label …