Simple Summary Cancer is driven by the excessive activity of growth-promoting genes and
deficient activity of the genes that restrain cell growth. Genes that suppress cell growth …

Oxidative stress and its end-products, such as 4-hydroxynonenal (HNE), initiate activation of
the Nuclear Factor Erythroid 2-Related Factor 2 (NRF2)/Kelch Like ECH Associated Protein …

Interleukin-4-induced-1 (IL4i1) is an amino acid oxidase secreted from immune cells. Recent
observations have suggested that IL4i1 is pro-tumorigenic via unknown mechanisms. As …

Recent studies have shown an association between maternal exposure to ambient fine
particle matter (PM2. 5) and congenital heart defects in the offspring, but the underlying …

Trichloroethylene (TCE), a widely used chlorinated solvent, is a common environmental
pollutant. Current evidence shows that TCE could induce heart defects during embryonic …

Polycyclic aromatic hydrocarbons (PAHs) may interact with multiple intracellular receptors
and related signaling pathways. We comprehensively evaluated the toxicity profiles of six …

Inhibition of complex I of the mitochondrial respiratory chain (cI) by rotenone and methyl-
phenylpyridinium (MPP+) leads to the degeneration of dopaminergic neurons in man and …

Historically, identifying carcinogens has relied primarily on tumor studies in rodents, which
require enormous resources in both money and time. In silico models have been developed …

Indole-benzimidazoles have recently gained attention due to their antiproliferative and
antiestrogenic effects. However, their structural similarities and molecular mechanisms …

Transcriptomic analysis is a powerful method in the utilization of New Approach Methods
(NAMs) for identifying mechanisms of toxicity and application to hazard characterization …