Chromosomal translocations and genomic instability are universal hallmarks of tumor cells.
While the molecular mechanisms leading to the formation of translocations are rapidly being …

Possible clastogenic and aneugenic effects of pesticides on human lymphocytes at
concentrations likely to be encountered in residential and occupational exposure were …

The purpose of the present study was to investigate as to what extent differences in the
linear energy transfer (LET) are reflected at the chromosomal level. For this study human …

It is well established that chromosomes exist in discrete territories (CTs) in interphase and
are positioned in a cell-type specific probabilistic manner. The relative localisation of …

Toxic effects of the antineoplastic drug irinotecan on human blood cells at concentrations of
9.0 µg/ml and 4.6 µg/ml were evaluated in vitro. Using the alkaline and neutral comet assay …

Abstract Duran, A., Barquinero, JF, Caballín, MR, Ribas, M. and Barrios, L. Persistence of
Radiation-Induced Chromosome Aberrations in a Long-Term Cell Culture. Radiat. Res. 171 …

A multicolored FISH (mFISH) technique was used to characterize the cytogenetic damage
associated with exposure to α-particle radiation with particular emphasis on the quality and …

Histone acetylation/deacetylation constitute the most relevant chromatin remodelling
mechanism to control DNA access to nuclear machinery as well as to mutagenic agents …

The study aims to investigate the effect of ionising radiation on the structure of the
chromosomes after lose-dose X-ray irradiation. The first aim was to investigate the changes …

Gene fusions have long been considered hallmarks of cancer. Efforts into characterization of
their prevalence, cause, and function have provided significant progress toward …