The inflammatory response to severe acute respiratory syndrome–related coronavirus 2
infection has a direct impact on the clinical outcomes of coronavirus disease 2019 patients …

Inflammation plays an essential role in the control of pathogens and in shaping the ensuing
adaptive immune responses. Traditionally, innate immunity has been described as a rapid …

The genome of SARS-CoV-2 encodes two viral proteases (NSP3/papain-like protease and
NSP5/3C-like protease) that are responsible for cleaving viral polyproteins during …

Oxidative stress is a major contributor to the pathogenesis of various inflammatory diseases.
Accumulating evidence has shown that oxidative stress is characterized by the …

Background The present review is part of the ESCMID Study Group for Infections in
Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and …

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emerged at the end of
2019 and caused the pandemic of coronavirus disease 2019 (COVID-19). Basic and clinical …

Celiac disease is an autoimmune disorder in which ingestion of dietary gluten triggers an
immune reaction in the small intestine leading to destruction of the lining epithelium. Current …

Since their discovery, members of the gasdermin (GSDM) family of proteins have been firmly
established as executors of pyroptosis, with the N-terminal fragment of most GSDMs capable …

TRAFs [tumor necrosis factor (TNF) receptor associated factors] are a family of signaling
molecules that function downstream of multiple receptor signaling pathways and play a …

Immune system activation is essential to thwart the invasion of pathogens and respond
appropriately to tissue damage. However, uncontrolled inflammation can result in extensive …