New technologies have enabled the investigation of biology and human health at an
unprecedented scale and in multiple dimensions. These dimensions include a myriad of …

Noncoding DNA regions have central roles in human biology, evolution, and disease.
ChromHMM helps to annotate the noncoding genome using epigenomic information across …

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a central method in
epigenomic research. Genome-wide analysis of histone modifications, such as enhancer …

Chromatin is folded into successive layers to organize linear DNA. Genes within the same
topologically associating domains (TADs) demonstrate similar expression and histone …

Sequencing technologies are evolving at a rapid pace, enabling the generation of massive
amounts of data in multiple dimensions (eg, genomics, epigenomics, transcriptomic …

Higher-order genome organization and its variation in different cellular conditions remain
poorly understood. Recent high-coverage genome-wide chromatin interaction mapping …

Recent progress in whole-genome mapping and imaging technologies has enabled the
characterization of the spatial organization and folding of the genome in the nucleus. In …

We report SPIN, an integrative computational method to reveal genome-wide intranuclear
chromosome positioning and nuclear compartmentalization relative to multiple nuclear …

The rapidly increasing quantity of genome-wide chromosome conformation capture data
presents great opportunities and challenges in the computational modeling and …

Mammalian genomes are partitioned into domains that replicate in a defined temporal order.
These domains can replicate at similar times in all cell types (constitutive) or at cell type …