Calcium regulates a wide spectrum of physiological processes such as heartbeat, muscle
contraction, neuronal communication, hormone release, cell division, and gene …

In the heart, adrenergic stimulation activates the β-adrenergic receptors coupled to the
heterotrimeric stimulatory Gs protein, followed by subsequent activation of adenylyl cyclase …

RGK proteins constitute a novel subfamily of small Ras-related proteins that function as
potent inhibitors of voltage-dependent (VDCC) Ca2+ channels and regulators of actin …

RGK proteins belong to the Ras superfamily of monomeric G-proteins, and currently include
four members—Rad, Rem, Rem2, and Gem/Kir. RGK proteins are broadly expressed, and …

Intracellular free Ca 2+ ions regulate many cellular functions, and in turn, the cell devotes
many genes/proteins to keep tight control of the level of intracellular free Ca 2+. Here, we …

CaV1/CaV2 channels, comprised of pore-forming α1 and auxiliary (β, α2δ) subunits, control
diverse biological responses in excitable cells. Molecules blocking CaV1/CaV2 channel …

Rationale: Rad (Ras associated with diabetes) GTPase, a monomeric small G protein, binds
to Cavβ subunit of the L-type Ca2+ channel (LCC) and thereby regulates LCC trafficking and …

L-type calcium channels (LTCC) impact the function of nearly all excitable cells. The
classical LTCC function is to mediate trans-sarcolemmal Ca2+ flux. This review focuses on …

The RGK family of small G-proteins, including Rad, Gem, Rem1, and Rem2, is inducibly
expressed in various mammalian tissues and interacts with voltage-dependent calcium …

In skeletal muscle, the L-type voltage-gated Ca 2+ channel (1, 4-dihydropyridine receptor)
serves as the voltage sensor for excitation-contraction (EC) coupling. In this study, we …