The metal ion hypothesis of Alzheimer's disease and the anti-neuroinflammatory effect of metal chelators

LL Chen, YG Fan, LX Zhao, Q Zhang, ZY Wang - Bioorganic chemistry, 2023 - Elsevier
Abstract Alzheimer's disease (AD), characterized by the β-amyloid protein (Aβ) deposition
and tau hyperphosphorylation, is the most common dementia with uncertain etiology. The …

Iron homeostasis disorder and Alzheimer's disease

Y Peng, X Chang, M Lang - International journal of molecular sciences, 2021 - mdpi.com
Iron is an essential trace metal for almost all organisms, including human; however,
oxidative stress can easily be caused when iron is in excess, producing toxicity to the human …

Elevated transferrin receptor impairs T cell metabolism and function in systemic lupus erythematosus

K Voss, AE Sewell, ES Krystofiak… - Science …, 2023 - science.org
T cells in systemic lupus erythematosus (SLE) exhibit multiple metabolic abnormalities.
Excess iron can impair mitochondria and may contribute to SLE. To gain insights into this …

The role of microglia in Alzheimer's disease from the perspective of immune inflammation and iron metabolism

HZ Long, ZW Zhou, Y Cheng, HY Luo, FJ Li… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD), the most common type of senile dementia, includes the complex
pathogenesis of abnormal deposition of amyloid beta-protein (Aβ), phosphorylated tau (p …

Iron dysregulation and inflammatory stress erythropoiesis associates with long-term outcome of COVID-19

AL Hanson, MP Mulè, H Ruffieux, F Mescia… - Nature …, 2024 - nature.com
Persistent symptoms following SARS-CoV-2 infection are increasingly reported, although
the drivers of post-acute sequelae (PASC) of COVID-19 are unclear. Here we assessed 214 …

Exploring whether iron sequestration within the CNS of patients with Alzheimer's disease causes a functional iron deficiency that advances neurodegeneration

SM LeVine, S Tsau, S Gunewardena - Brain Sciences, 2023 - mdpi.com
The involvement of iron in the pathogenesis of Alzheimer's disease (AD) may be
multifaceted. Besides potentially inducing oxidative damage, the bioavailability of iron may …

The Azalea Hypothesis of Alzheimer Disease: A Functional Iron Deficiency Promotes Neurodegeneration

SM LeVine - The Neuroscientist, 2024 - journals.sagepub.com
Chlorosis in azaleas is characterized by an interveinal yellowing of leaves that is typically
caused by a deficiency of iron. This condition is usually due to the inability of cells to …

Brain transcriptome analysis reveals subtle effects on mitochondrial function and iron homeostasis of mutations in the SORL1 gene implicated in early onset familial …

K Barthelson, SM Pederson, M Newman, M Lardelli - Molecular Brain, 2020 - Springer
To prevent or delay the onset of Alzheimer's disease (AD), we must understand its molecular
basis. The great majority of AD cases arise sporadically with a late onset after 65 years of …

An alternative view of familial Alzheimer's disease genetics

M Lardelli - Journal of Alzheimer's Disease, 2023 - content.iospress.com
Probabilistic and parsimony-based arguments regarding available genetics data are used to
propose that Hardy and Higgin's amyloid cascade hypothesis is valid but is commonly …

[HTML][HTML] SuanZaoRen decoction alleviates neuronal loss, synaptic damage and ferroptosis of AD via activating DJ-1/Nrf2 signaling pathway

Q Long, T Li, Q Zhu, L He, B Zhao - Journal of Ethnopharmacology, 2024 - Elsevier
Abstract Ethnopharmacological relevance SuanZaoRen Decoction (SZRD), a famous herbal
prescription, and has been widely proven to have positive therapeutic effects on insomnia …