The world continues to contend with successive waves of coronavirus disease 2019 (COVID-
19), fueled by the emergence of viral variants. At the same time, persistent, prolonged and …

CD8+ T cells specific for cancer cells are detected within tumours. However, despite their
presence, tumours progress. The clinical success of immune checkpoint blockade and …

Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …

Molecular mimicry is one of the leading mechanisms by which infectious or chemical agents
may induce autoimmunity. It occurs when similarities between foreign and self-peptides …

While inbred mice have informed most of what we know about the immune system in the
modern era, they have clear limitations with respect to their ability to be informative …

CD8 T cell activation and differentiation are tightly controlled, and dependent on the context
in which naïve T cells encounter antigen, can either result in functional memory or T cell …

The ability of mammals to mount adaptive immune responses culminating with the
establishment of immunological memory is predicated on the ability of the mature T cell …

To identify disease-relevant T cell receptors (TCRs) with shared antigen specificity, we
analyzed 778,938 TCRβ chain sequences from 178 non-small cell lung cancer patients …

In this work, we find that CD8+ T cells expressing inhibitory killer cell immunoglobulin-like
receptors (KIRs) are the human equivalent of Ly49+ CD8+ regulatory T cells in mice and are …

A variety of mechanisms have been suggested as the means by which infections can initiate
and/or exacerbate autoimmune diseases. One mechanism is molecular mimicry, where a …