Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Recent transcriptomic, histological and functional studies have begun to shine light on the
fibroblasts present in the meninges, choroid plexus and perivascular spaces of the brain and …

Leptomeninges, consisting of the pia mater and arachnoid, form a connective tissue
investment and barrier enclosure of the brain. The exact nature of leptomeningeal cells has …

Fibrosis is a common pathological response to inflammation in many peripheral tissues and
can prevent tissue regeneration and repair. Here, we identified persistent fibrotic scarring in …

The meninges are the fibrous covering of the central nervous system (CNS) which contain
vastly heterogeneous cell types within its three layers (dura, arachnoid, and pia). The dural …

Fibrotic scar tissue limits central nervous system regeneration in adult mammals. The extent
of fibrotic tissue generation and distribution of stromal cells across different lesions in the …

Central nervous system (CNS) trauma activates a persistent repair response that leads to
fibrotic scar formation within the lesion. This scarring is similar to other organ fibrosis in …

Blood vessels are vital to sustain life in all vertebrates. While it is known that mural cells
(pericytes and smooth muscle cells) regulate vascular integrity, the contribution of other cell …

The process of uncontrolled internal scarring, called fibrosis, is now emerging as a
pathological feature shared by both peripheral and central nervous system diseases. In the …

Perivascular fibroblasts (PVFs) are recognized for their pro-fibrotic role in many central
nervous system disorders. Like mural cells, PVFs surround blood vessels and express …