Abstract Endothelin-1 (ET-1), a peptide produced primarily by vascular endothelial cells,
was discovered in 1980 and it was characterized as a powerful vasoconstrictor and mitogen …

Pulmonary arterial hypertension (PAH) is a rare but debilitating disease, which if left
untreated rapidly progresses to right ventricular failure and eventually death. In the quest to …

There is now increasing evidence that endothelial dysfunction is an early event in the
pathophysiology of cardiovascular diseases and can be corrected with certain therapies …

Recent data demonstrate the fundamental role of endothelin in the pathogenesis of fibrosis,
and the anti‐fibrotic potential of dual endothelin receptor antagonists such as bosentan …

The potent coronary vasoconstrictor, endothelin‐1 (ET‐1) may also regulate neutrophil traffic
into tissues. The aim of the present study was to characterize the endothelin receptors …

Objective To explore a possible correlation between endothelin 1 (ET‐1), the most potent
endothelium‐derived contracting factor that modulates vascular smooth muscle tone, and …

MixedConnective Tissue Disease Page 1 REVIEW ARTICLE MixedConnective Tissue Disease
Reiji Kasukawa Mixedconnective tissue disease deserves to bea distinct disease entity due to …

Pulmonary arterial hypertension is a well-known complication of connective tissue diseases
such as systemic sclerosis, systemic lupus erythematosus, mixed connective tissue …

The endothelin system participates in a number of critical biologic pathways, including
normal wound healing. In addition, emerging basic science, and animal and human data all …

Primary pulmonary hypertension (PPH) is a rare disease that affects young people
predominantly of female gender. Early epidemiologic studies have shown that the diagnosis …