The role of oxidative stress in pancreatic β cell dysfunction in diabetes

N Eguchi, ND Vaziri, DC Dafoe, H Ichii - International journal of molecular …, 2021 - mdpi.com
Diabetes is a chronic metabolic disorder characterized by inappropriately elevated glucose
levels as a result of impaired pancreatic β cell function and insulin resistance. Extensive …

Molecular mechanism of lipotoxicity as an interesting aspect in the development of pathological states—current view of knowledge

K Lipke, A Kubis-Kubiak, A Piwowar - Cells, 2022 - mdpi.com
Free fatty acids (FFAs) play numerous vital roles in the organism, such as contribution to
energy generation and reserve, serving as an essential component of the cell membrane, or …

Boosting the yields of microalgal biomass and high-value added products by phytohormones: A mechanistic insight using transcriptomics

JM Xu, JQ Xiong - Journal of Cleaner Production, 2023 - Elsevier
Addition of phytohormones (diethyl aminoethyl hexanoate and indole acetic acid) at 10− 5 M
significantly increased the growth of a green microalga, Chlorella pyrenoidosa up to 62.25 …

Loss of p53 sensitizes cells to palmitic acid-induced apoptosis by reactive oxygen species accumulation

G Yu, H Luo, N Zhang, Y Wang, Y Li, H Huang… - International journal of …, 2019 - mdpi.com
Palmitic acid, the most common saturated free fatty acid, can lead to lipotoxicity and
apoptosis when overloaded in non-fat cells. Palmitic acid accumulation can induce …

Branched chain amino acids—friend or foe in the control of energy substrate turnover and insulin sensitivity?

E Supruniuk, E Żebrowska… - Critical Reviews in Food …, 2023 - Taylor & Francis
Branched chain amino acids (BCAA) and their derivatives are bioactive molecules with
pleiotropic functions in the human body. Elevated fasting blood BCAA concentrations are …

Research progress on drugs for diabetes based on insulin receptor/insulin receptor substrate

J Su, L Tang, Y Luo, J Xu, S Ouyang - Biochemical Pharmacology, 2023 - Elsevier
The number of people with diabetes worldwide is increasing annually, resulting in a serious
economic burden. Insulin resistance is a major pathology in the early onset of diabetes …

Mitochondrial reprogramming in peripheral blood mononuclear cells of patients with glycogen storage disease type Ia

A Rossi, A Assunto, C Rosano, S Tucci, M Ruoppolo… - Genes & nutrition, 2023 - Springer
Background Glycogen storage disease type Ia (GSDIa) is an inborn metabolic disorder
caused by the deficiency of glucose-6-phospatase-α (G6Pase-α) leading to mitochondrial …

Metabolite profiles of diabetes mellitus and response to intervention in anti-hyperglycemic drugs

Y Liu, D Wang, YP Liu - Frontiers in Endocrinology, 2023 - frontiersin.org
Type 2 diabetes mellitus (T2DM) has become a major health problem, threatening the
quality of life of nearly 500 million patients worldwide. As a typical multifactorial metabolic …

Polysaccharides from Opuntia milpa alta alleviate alloxan-induced INS-1 cells apoptosis via reducing oxidative stress and upregulating Nrf2 expression

W Li, K Lin, M Zhou, Q Xiong, C Li, Q Ru - Nutrition Research, 2020 - Elsevier
The incidence and progression of type 2 diabetes are closely related to pancreatic β-cell
damage. Oxidative stress may be one of the key factors contributing to β-cell apoptosis …

Branched-chain amino acids and their interactions with lipid metabolites for increased risk of gestational diabetes

N Li, J Li, H Wang, J Liu, W Li, K Yang… - The Journal of …, 2022 - academic.oup.com
Objective We aimed to explore associations of branched-chain amino acids (BCAA) in early
pregnancy with gestational diabetes mellitus (GDM), and whether high BCAAs and …