The pharmacology of L-DOPA-induced dyskinesia in Parkinson's disease
Abstract l-3, 4-Dihydroxyphenylalanine (l-DOPA) remains the most effective symptomatic
treatment of Parkinson's disease (PD). However, long-term administration of l-DOPA is …
treatment of Parkinson's disease (PD). However, long-term administration of l-DOPA is …
Shedding light on thyroid hormone disorders and Parkinson disease pathology: mechanisms and risk factors
Parkinson's disease (PD) is a neurodegenerative disorder characterized by loss of
dopaminergic neurons. Dopaminergic system is interconnected with the hypothalamic …
dopaminergic neurons. Dopaminergic system is interconnected with the hypothalamic …
Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia
M Heiman, A Heilbut, V Francardo… - Proceedings of the …, 2014 - National Acad Sciences
Levodopa treatment is the major pharmacotherapy for Parkinson's disease. However, almost
all patients receiving levodopa eventually develop debilitating involuntary movements …
all patients receiving levodopa eventually develop debilitating involuntary movements …
Targeting serum response factor (SRF) deactivates ΔFosB and mitigates Levodopa-induced dyskinesia in a mouse model of Parkinson's disease
Abstract L-3, 4-dihydroxyphenylalanine (L-DOPA) is currently the preferred treatment for
Parkinson's Disease (PD) and is considered the gold standard. However, prolonged use of L …
Parkinson's Disease (PD) and is considered the gold standard. However, prolonged use of L …
Dopamine signaling leads to loss of Polycomb repression and aberrant gene activation in experimental parkinsonism
Polycomb group (PcG) proteins bind to and repress genes in embryonic stem cells through
lineage commitment to the terminal differentiated state. PcG repressed genes are commonly …
lineage commitment to the terminal differentiated state. PcG repressed genes are commonly …
[HTML][HTML] The role of Thyrotropin Releasing Hormone in aging and neurodegenerative diseases
CM Daimon, P Chirdon, S Maudsley… - American journal of …, 2013 - ncbi.nlm.nih.gov
Thyrotropin releasing hormone (TRH) is primarily known as the central regulator of the
hypothalamic-pituitary-thyroid (HPT) axis. However, TRH also exerts a variety of central …
hypothalamic-pituitary-thyroid (HPT) axis. However, TRH also exerts a variety of central …
Taltirelin induces TH expression by regulating TRHR and RARα in medium spiny neurons
K Zhu, L Meng, J Luo, T Wen, L Dan, Z Wang… - Journal of Translational …, 2024 - Springer
Taltirelin, an orally effective thyrotropin-releasing hormone analog, significantly improves
motor impairments in rat models of Parkinson's disease (PD) and enhances dopamine …
motor impairments in rat models of Parkinson's disease (PD) and enhances dopamine …
Thyroid hormone levels and structural parameters of thyroid homeostasis are correlated with motor subtype and disease severity in euthyroid patients with Parkinson's …
Y Tan, L Gao, Q Yin, Z Sun, X Man, Y Du… - International Journal of …, 2021 - Taylor & Francis
Purpose: This study is to investigate the relationship between thyroid function and
Parkinson's disease (PD). Materials and Methods: Totally 77 PD patients were included …
Parkinson's disease (PD). Materials and Methods: Totally 77 PD patients were included …
Striatal Nurr1, but not FosB expression links a levodopa-induced dyskinesia phenotype to genotype in Fisher 344 vs. Lewis hemiparkinsonian rats
K Steece-Collier, TJ Collier, JW Lipton, JA Stancati… - Experimental …, 2020 - Elsevier
Numerous genes, and alterations in their expression, have been identified as risk factors for
developing levodopa-induced dyskinesia (LID). However, our understanding of the …
developing levodopa-induced dyskinesia (LID). However, our understanding of the …
[HTML][HTML] Expanding the search for genetic biomarkers of Parkinson's disease into the living brain
Altered gene expression related to Parkinson's Disease (PD) has not been described in the
living brain, yet this information may support novel discovery pertinent to disease …
living brain, yet this information may support novel discovery pertinent to disease …