Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

The past two decades have seen a rise in the number of investigations examining the health-
related effects of religiously motivated fasts. Islamic Ramadan is a 28-30 day fast in which …

Recent evidence points to a strong relationship between increased mitochondrial
biogenesis and increased survival in eukaryotes. Branched-chain amino acids (BCAAs) …

An updated version of the mitochondrial free radical theory of aging (MFRTA) and longevity
is reviewed. Key aspects of the theory are emphasized. Another main focus concerns …

Febrifugine, the bioactive constituent of one of the 50 fundamental herbs of traditional
Chinese medicine, has been characterized for its therapeutic activity, though its molecular …

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …

The mitochondrial free radical theory of aging is reviewed. Only two parameters currently
correlate with species longevity in the right sense: the mitochondrial rate of reactive oxygen …

The nonenzymatic adduction of malondialdehyde (MDA) to the protein amino groups leads
to the formation of malondialdehyde-lysine (MDALys). The degree of unsaturation of …

Considerable interest has been shown in the ability of caloric restriction (CR) to improve
multiple parameters of health and to extend lifespan. CR is the reduction of caloric intake …

Comparative studies indicate that long-lived mammals have low rates of mitochondrial
reactive oxygen species production (mtROSp) and oxidative damage in their mitochondrial …