Monoclonal antibodies targeting small airways: a new perspective for biological therapies in severe asthma

C Lombardi, M Cottini, A Berti, P Comberiati - Asthma Research and …, 2022 - Springer
Small airway dysfunction (SAD) in asthma is characterized by the inflammation and
narrowing of airways with less of 2 mm in diameter between generations 8 and 23 of the …

Early benefit of mepolizumab on small airways in severe asthma: insights from IMPOSE study

OS Kotsiou, P Kirgou, D Siachpazidou… - ERJ Open …, 2024 - publications.ersnet.org
Background Severe eosinophilic asthma adversely affects small airway function, but
effective therapeutic options are limited. The IMPOSE trial (NCT05147155) assessed the …