Abstract MicroRNAs (miRNAs), small non-coding RNAs, can regulate post-transcriptional
gene expressions and silence a broad set of target genes. miRNAs, aberrantly expressed in …

Kinesin motor proteins comprise an ATPase superfamily that works hand in hand with
microtubules in every eukaryote. The mitotic kinesins, by virtue of their potential therapeutic …

The results of administering escalating, iv doses of targeted nanoparticles containing a
siRNA targeting the M2 subunit of ribonucleotide reductase to non-human primates are …

The phenomenon of RNAi, in which the introduction of dsRNA into a cell triggers the
destruction of the corresponding mRNA resulting in a gene silencing effect, is conserved …

Synthetic siRNA technology has emerged as a promising approach for molecular therapy of
cancer but, despite its potential for post‐transcriptional gene silencing, there is an urgent …

Two major classes of small regulatory RNAs—small interfering RNAs (siRNAs) and
microRNA (miRNAs)—are involved in a common RNA interference processing pathway …

Human adenoviruses are a common threat to immunocompromised patients, eg, HIV-
positive individuals or solid-organ and, in particular, allogeneic stem cell transplant …

Background Vascular endothelial growth factor (VEGF) is involved in the growth of new
blood vessels that feed tumors and kinesin spindle protein (KSP) plays a critical role in …

Hemagglutinating virus of Japan envelope (HVJ-E) vector with inactivated replication-
defective Sendai virus was originally developed as a versatile drug delivery system …

Cotransfection of a mixture of siRNAs species is typically used when simultaneous targeting
of more than one mRNA is required. However, competition between siRNAs could occur and …