Selective chemical protein modification

CD Spicer, BG Davis - Nature communications, 2014 - nature.com
Chemical modification of proteins is an important tool for probing natural systems, creating
therapeutic conjugates and generating novel protein constructs. Site-selective reactions …

Glycosylation of therapeutic proteins: an effective strategy to optimize efficacy

RJ Solá, K Griebenow - BioDrugs, 2010 - Springer
During their development and administration, protein-based drugs routinely display
suboptimal therapeutic efficacies due to their poor physicochemical and pharmacological …

[HTML][HTML] Analysis and optimization of copper-catalyzed azide–alkyne cycloaddition for bioconjugation

V Hong, SI Presolski, C Ma, MG Finn - … Chemie (International ed. in …, 2009 - ncbi.nlm.nih.gov
Since its discovery in 2002, the copper-catalyzed azide-alkyne cycloaddition (CuAAC)[1]
reaction—the most widely recognized example of click chemistry [2]—has been rapidly …

Glycoprotein synthesis: an update

DP Gamblin, EM Scanlan, BG Davis - Chemical Reviews, 2009 - ACS Publications
1.1 Aims This review updates our original review on the synthesis of glycoproteins.(1) Its
aims, therefore, are 2-fold: to highlight, first, key developments since 2002 and, second …

Thiyl glycosylation of olefinic proteins: S‐linked glycoconjugate synthesis

N Floyd, B Vijayakrishnan, JR Koeppe… - Angewandte Chemie …, 2009 - Wiley Online Library
Over half of all proteins in nature are estimated to be glycosylated,[1] and these
biomolecules play key roles in protein expression, folding and stability [2–7] and are …

Nonnatural amino acids for site-specific protein conjugation

AJ De Graaf, M Kooijman, WE Hennink… - Bioconjugate …, 2009 - ACS Publications
Over the years, several chemical reactions have been developed that enable the covalent
conjugation of synthetic molecules to natural proteins. The resulting bioconjugates have …

Experimental investigation on the mechanism of chelation-assisted, copper (II) acetate-accelerated azide–alkyne cycloaddition

GC Kuang, PM Guha, WS Brotherton… - Journal of the …, 2011 - ACS Publications
A mechanistic model is formulated to account for the high reactivity of chelating azides
(organic azides capable of chelation-assisted metal coordination at the alkylated azido …

QuaNCAT: quantitating proteome dynamics in primary cells

AJM Howden, V Geoghegan, K Katsch, G Efstathiou… - Nature …, 2013 - nature.com
Here we demonstrate quantitation of stimuli-induced proteome dynamics in primary cells by
combining the power of bio-orthogonal noncanonical amino acid tagging (BONCAT) and …

Recent progress in chemical modification of proteins

S Sakamoto, I Hamachi - Analytical Sciences, 2019 - jstage.jst.go.jp
Chemical modification of proteins is important for creating a myriad of engineered proteins
and for elucidating the function and dynamics of proteins in live cells. A wide variety of …

C‐Glycoside Synthesis Enabled by Nickel Catalysis

W Shang, R Shi, D Niu - Chinese Journal of Chemistry, 2023 - Wiley Online Library
Comprehensive Summary C‐Glycosides are critical, naturally occurring products and
medicinal candidates, and extensive efforts have been made to explore efficient approaches …