Mesenchymal stem cells for neurological disorders

A Andrzejewska, S Dabrowska, B Lukomska… - Advanced …, 2021 - Wiley Online Library
Neurological disorders are becoming a growing burden as society ages, and there is a
compelling need to address this spiraling problem. Stem cell‐based regenerative medicine …

Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications

K Venkatesh, SK Ghosh, M Mullick… - Cell and tissue …, 2019 - Springer
Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a
prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites …

[HTML][HTML] Mesenchymal stem cell-derived exosomes reduce A1 astrocytes via downregulation of phosphorylated NFκB P65 subunit in spinal cord injury

L Wang, S Pei, L Han, B Guo, Y Li, R Duan… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Neurotoxic A1 astrocytes are induced by inflammation after spinal cord
injury (SCI), and the inflammation-related Nuclear Factor Kappa B (NFκB) pathway may be …

Intravenously delivered mesenchymal stem cell-derived exosomes target M2-type macrophages in the injured spinal cord

KL Lankford, EJ Arroyo, K Nazimek, K Bryniarski… - PloS one, 2018 - journals.plos.org
In a previous report we showed that intravenous infusion of bone marrow-derived
mesenchymal stem cells (MSCs) improved functional recovery after contusive spinal cord …

Umbilical mesenchymal stem cell-derived exosomes facilitate spinal cord functional recovery through the miR-199a-3p/145-5p-mediated NGF/TrkA signaling pathway …

Y Wang, X Lai, D Wu, B Liu, N Wang… - Stem cell research & …, 2021 - Springer
Background Although exosomes, as byproducts of human umbilical cord mesenchymal stem
cells (hUC-MSCs), have been demonstrated to be an effective therapy for traumatic spinal …

Molecular mechanisms and clinical application of multipotent stem cells for spinal cord injury

M Szymoniuk, J Litak, L Sakwa, A Dryla, W Zezuliński… - Cells, 2022 - mdpi.com
Spinal Cord Injury (SCI) is a common neurological disorder with devastating psychical and
psychosocial sequelae. The majority of patients after SCI suffer from permanent disability …

Regenerative stem cell therapy for neurodegenerative diseases: an overview

F Sivandzade, L Cucullo - International journal of molecular sciences, 2021 - mdpi.com
Neurodegenerative diseases resulting from the progressive loss of structure and/or function
of neurons contribute to different paralysis degrees and loss of cognition and sensation. The …

Small extracellular vesicles released by infused mesenchymal stromal cells target M2 macrophages and promote TGF‐β upregulation, microvascular stabilization and …

M Nakazaki, T Morita, KL Lankford… - Journal of …, 2021 - Wiley Online Library
Intravenous (IV) infusion of bone marrow‐derived mesenchymal stem/stromal cells (MSCs)
stabilizes the blood‐spinal cord barrier (BSCB) and improves functional recovery in …

Stem cells therapy for spinal cord injury: an overview of clinical trials

S Silvestro, P Bramanti, O Trubiani… - International Journal of …, 2020 - mdpi.com
Spinal cord injury (SCI) is a traumatic lesion that causes disability with temporary or
permanent sensory and/or motor deficits. The pharmacological approach still in use for the …

Biomaterial-supported MSC transplantation enhances cell–cell communication for spinal cord injury

B Lv, X Zhang, J Yuan, Y Chen, H Ding, X Cao… - Stem Cell Research & …, 2021 - Springer
The spinal cord is part of the central nervous system (CNS) and serves to connect the brain
to the peripheral nervous system and peripheral tissues. The cell types that primarily …