Mucosal vaccines, sterilizing immunity, and the future of SARS-CoV-2 virulence

D Focosi, F Maggi, A Casadevall - Viruses, 2022 - mdpi.com
Sterilizing immunity after vaccination is desirable to prevent the spread of infection from
vaccinees, which can be especially dangerous in hospital settings while managing frail …

Preclinical immunogenicity and efficacy of a candidate COVID-19 vaccine based on a vesicular stomatitis virus-SARS-CoV-2 chimera

AS Espeseth, M Yuan, M Citron, L Reiserova… - …, 2022 - thelancet.com
Background To investigate a vaccine technology with potential to protect against
coronavirus disease 2019 (COVID-19) and reduce transmission of severe acute respiratory …

Current status of mucosal vaccines against SARS-CoV2: a hope for protective immunity

I García-Silva, DO Govea-Alonso… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The current vaccines used to fight against COVID-19 are effective, however the
induction of protective immunity is a pending goal required to prevent viral transmission …

Surface-modified measles vaccines encoding oligomeric, prefusion-stabilized SARS-CoV-2 spike glycoproteins boost neutralizing antibody responses to Omicron and …

MÁ Muñoz-Alía, RA Nace, B Balakrishnan, L Zhang… - Mbio, 2024 - Am Soc Microbiol
Serum titers of SARS-CoV-2-neutralizing antibodies (nAbs) correlate well with protection
from symptomatic COVID-19 but decay rapidly in the months following vaccination or …

Optimized intramuscular immunization with VSV-vectored spike protein triggers a superior immune response to SARS-CoV-2

A Taddeo, IB Veiga, C Devisme, R Boss, P Plattet… - NPJ vaccines, 2022 - nature.com
Immunization with vesicular stomatitis virus (VSV)-vectored COVID-19 vaccine candidates
expressing the SARS-CoV-2 spike protein in place of the VSV glycoprotein relies implicitly …

Oral immunization with rVSV bivalent vaccine elicits protective immune responses, including ADCC, against both SARS-CoV-2 and Influenza A viruses

MJ Ouyang, Z Ao, TA Olukitibi, P Lawrynuik, C Shieh… - Vaccines, 2023 - mdpi.com
COVID-19 and influenza both cause enormous disease burdens, and vaccines are the
primary measures for their control. Since these viral diseases are transmitted through the …

Short-lived antibody-mediated saliva immunity against SARS-CoV-2 after vaccination

JR Madsen, BE Holm, L Pérez-Alós… - Microbiology …, 2023 - Am Soc Microbiol
Knowledge about the effect of vaccination against severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) on immunity reflected in the saliva is sparse. We examined the …

An Algae-Made RBD from SARS-CoV-2 Is Immunogenic in Mice

DO Govea-Alonso, A Malla, OC Bolaños-Martínez… - Pharmaceuticals, 2022 - mdpi.com
Despite the current advances in global vaccination against SARS-CoV-2, boosting is still
required to sustain immunity in the population, and the induction of sterilizing immunity …

Thinking Outside the Box: Utilizing Nontraditional Animal Models for COVID-19 Research

S Gunasekara, M Tamil Selvan, CA Miller… - International Journal of …, 2022 - mdpi.com
The ongoing COVID-19 pandemic continues to affect the lives, wellbeing, and stability of
communities worldwide. The race to save human lives is critical, and the development of …

[HTML][HTML] Surface-modified measles vaccines encoding oligomeric, fusion-stabilized SARS-CoV-2 spike glycoproteins bypass measles seropositivity, boosting …

MÁ Muñoz-Alía, RA Nace, B Balakrishnan, L Zhang… - bioRxiv, 2022 - ncbi.nlm.nih.gov
Serum titers of SARS-CoV-2 neutralizing antibodies (nAb) correlate well with protection from
symptomatic COVID-19, but decay rapidly in the months following vaccination or infection. In …