Geraniol is a monoterpenic alcohol with a pleasant rose-like aroma, known as an important
ingredient in many essential oils, and is used commercially as a fragrance compound in …

This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …

Animals have developed the means for supporting complex and dynamic consortia of
microorganisms during their life cycle. A transcendent view of vertebrate biology therefore …

This review brings you up-to-date with the hepatocyte research on: 1) in vitro–in vivo
correlations of metabolism and clearance; 2) CYP enzyme induction, regulation, and cross …

Cytochrome P450 2B6 (CYP2B6) belongs to the minor drug metabolizing P450s in human
liver. Expression is highly variable both between individuals and within individuals, owing to …

▪ Abstract The metabolic nuclear receptors act as metabolic and toxicological sensors,
enabling the organism to quickly adapt to environmental changes by inducing the …

Objectives: Efavirenz is an effective antiretroviral agent, but central nervous system side
effects occur commonly, and population (racial) differences in pharmacokinetics and …

The human cytochrome P450, CYP2B6, is involved in the metabolism of several
therapeutically important drugs and environmental or abused toxicants. In this study, we …

Considerable support exists for the roles of metabolism in modulating the carcinogenic
properties of chemicals. In particular, many of these compounds are pro-carcinogens that …

The cytochrome P450s are responsible for about 75% of phase I dependent drug
metabolism and for the metabolism of a huge amount of dietary constituents and …