Advances in mechanical biomarkers

M Eroles, F Rico - Journal of Molecular Recognition, 2023 - Wiley Online Library
Mechanical biomarkers distinguish health conditions through quantitative mechanical
measurements. The emergence and establishment of nanotechnology in the last decades …

Profiling native pulmonary basement membrane stiffness using atomic force microscopy

B Hartmann, L Fleischhauer, M Nicolau, THL Jensen… - Nature protocols, 2024 - nature.com
Mammalian cells sense and react to the mechanics of their immediate microenvironment.
Therefore, the characterization of the biomechanical properties of tissues with high spatial …

Correlation between biological and mechanical properties of extracellular matrix from colorectal peritoneal metastases in human tissues

E Lorenc, L Varinelli, M Chighizola, S Brich, F Pisati… - Scientific Reports, 2023 - nature.com
Peritoneal metastases (PM) are common routes of dissemination for colorectal cancer
(CRC) and remain a lethal disease with a poor prognosis. The properties of the extracellular …

Lung micrometastases display ECM depletion and softening while macrometastases are 30-fold stiffer and enriched in fibronectin

M Narciso, Á Martínez, C Júnior, N Díaz-Valdivia… - Cancers, 2023 - mdpi.com
Simple Summary This study examined the mechanical properties of the extracellular matrix
(ECM) in lung metastases from two cancer models: lung carcinoma and melanoma. The …

Development of a Novel Biomarker for the Progression of Idiopathic Pulmonary Fibrosis

HJ Yeo, M Ha, DH Shin, HR Lee, YH Kim… - International Journal of …, 2024 - mdpi.com
The progression of idiopathic pulmonary fibrosis (IPF) is diverse and unpredictable. We
identified and validated a new biomarker for IPF progression. To identify a candidate gene to …

Effects of aging on the biomechanical properties of the lung extracellular matrix: dependence on tissular stretch

A Ulldemolins, M Narciso, H Sanz-Fraile… - Frontiers in Cell and …, 2024 - frontiersin.org
Introduction: Aging induces functional and structural changes in the lung, characterized by a
decline in elasticity and diminished pulmonary remodeling and regenerative capacity …

Atomic force microscopy in disease‐related studies: Exploring tissue and cell mechanics

S Liu, Y Han, L Kong, G Wang… - Microscopy Research and …, 2024 - Wiley Online Library
Despite significant progress in human medicine, certain diseases remain challenging to
promptly diagnose and treat. Hence, the imperative lies in the development of more …

[PDF][PDF] Extracellular matrix mediated resistance in solid tumors against cell-based immunotherapy

K Sit - 2024 - studenttheses.uu.nl
Cell-based immunotherapies like immune checkpoint blockade and CAR T-cell are powerful
weapons in the battle against cancer. Despite the clinical successes in treating …

AFM automation for mechanically characterizing biological samples at different scales

JL Alonso - 2023 - theses.hal.science
In recent years, there has been a significant rise in the study of cellular and extracellular
matrix (ECM) mechanics, driven by the recognition of its crucial role in physiological and …

[PDF][PDF] Impact of cigarette smoke on inflammasome-dependent responses in human lung fibroblasts

IL COORDINATORE, IL TUTOR, IL CO-TUTOR - iris.unipa.it
Chronic Obstructive Pulmonary Disease (COPD) is a common and persistent airway disease
associated with limitation in airflow. According to the Global Burden of Disease Study 2019 …