Parkinson's disease (PD) and frontotemporal dementia/amyotrophic lateral sclerosis
(FTD/ALS) are insidious and incurable neurodegenerative diseases that represent a …

Lysosomal proteases play a crucial role in maintaining cell homeostasis. Human cathepsin
D manages protein turnover degrading misfolded and aggregated proteins and favors …

Various post-translationally modified (PTM) proteoforms of alpha-synuclein (aSyn)—
including C-terminally truncated (CTT) and Serine 129 phosphorylated (Ser129-p) aSyn …

Aging-related tau astrogliopathy (ARTAG) describes tau pathology in astrocytes in different
locations and anatomical regions. In the present study we addressed the question of …

Abstract Multiple System Atrophy is characterized pathologically by the accumulation of
alpha-synuclein (aSyn) into glial cytoplasmic inclusions (GCIs). The mechanism underlying …

Accumulation of the neuronal protein SNCA/alpha-synuclein and of the oligodendroglial
phosphoprotein TPPP/p25A within the glial cytoplasmic inclusions (GCIs) represents the key …

Extrapyramidal movement disorders include hypokinetic rigid and hyperkinetic or mixed
forms, most of them originating from dysfunction of the basal ganglia (BG) and their …

Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized
by striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA), and …

Previous genetic studies on hereditary Parkinson's disease (PD) have identified a set of
pathogenic gene mutations that have strong impacts on the pathogenicity of PD. In addition …

Aging is associated with a gradual decline of cellular proteostasis, giving rise to devastating
protein misfolding diseases, such as Alzheimer disease (AD) or Parkinson disease (PD) …