Pathobiology of Helicobacter pylori–induced gastric cancer

M Amieva, RM Peek Jr - Gastroenterology, 2016 - Elsevier
Colonization of the human stomach by Helicobacter pylori and its role in causing gastric
cancer is one of the richest examples of a complex relationship among human cells …

Molecular anatomy and pathogenic actions of Helicobacter pylori CagA that underpin gastric carcinogenesis

A Takahashi-Kanemitsu, CT Knight… - Cellular & molecular …, 2020 - nature.com
Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor for
gastric cancer. The cagA gene product, CagA, is delivered into gastric epithelial cells via the …

Helicobacter pylori CagA and gastric cancer: a paradigm for hit-and-run carcinogenesis

M Hatakeyama - Cell host & microbe, 2014 - cell.com
Helicobacter pylori is a gastric bacterial pathogen that is etiologically linked to human gastric
cancer. The cytotoxin-associated gene A (CagA) protein of H. pylori, which is delivered into …

Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis

S Imai, T Ooki, N Murata-Kamiya, D Komura… - Cell Host & Microbe, 2021 - cell.com
Summary Infection with CagA-producing Helicobacter pylori plays a causative role in the
development of gastric cancer. Upon delivery into gastric epithelial cells, CagA deregulates …

Structure and function of Helicobacter pylori CagA, the first-identified bacterial protein involved in human cancer

M Hatakeyama - Proceedings of the Japan Academy, Series B, 2017 - jstage.jst.go.jp
Chronic infection with Helicobacter pylori cagA-positive strains is the strongest risk factor of
gastric cancer. The cagA gene-encoded CagA protein is delivered into gastric epithelial …

[HTML][HTML] Role of the Wnt/β-catenin pathway in gastric cancer: An in-depth literature review

MA Chiurillo - World journal of experimental medicine, 2015 - ncbi.nlm.nih.gov
Gastric cancer remains one of the most common cancers worldwide and one of the leading
cause for cancer-related deaths. Gastric adenocarcinoma is a multifactorial disease that is …

The impact of the human microbiome in tumorigenesis, cancer progression, and biotherapeutic development

CM Doocey, K Finn, C Murphy, CM Guinane - BMC microbiology, 2022 - Springer
Background Cancer impacts millions of lives globally each year, with approximately 10
million cancer-related deaths recorded worldwide in 2020. Mounting research has …

Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways

X Yong, B Tang, BS Li, R Xie, CJ Hu, G Luo… - Cell communication and …, 2015 - Springer
Helicobacter pylori (H. pylori) infection is strongly associated with the development of gastric
diseases but also with several extragastric diseases. The clinical outcomes caused by H …

Helicobacter pylori diversity and gastric cancer risk

TL Cover - MBio, 2016 - Am Soc Microbiol
Gastric cancer is a leading cause of cancer-related death worldwide. Helicobacter pylori
infection is the strongest known risk factor for this malignancy. An important goal is to identify …

The Helicobacter pylori cag type IV secretion system

TL Cover, DB Lacy, MD Ohi - Trends in microbiology, 2020 - cell.com
Colonization of the human stomach with Helicobacter pylori strains containing the cag
pathogenicity island is a risk factor for development of gastric cancer. The cag pathogenicity …