Macrophages infiltrating tumour tissues or residing in the microenvironment of solid tumours
are known as tumour-associated macrophages (TAMs). These specialized immune cells …

Intratumor heterogeneity, which fosters tumor evolution, is a key challenge in cancer
medicine. Here, we review data and technologies that have revealed intra-tumor …

Macrophages are crucial drivers of tumour-promoting inflammation. Tumour-associated
macrophages (TAMs) contribute to tumour progression at different levels: by promoting …

The tumor microenvironment significantly influences therapeutic response and clinical
outcome. Microenvironment-mediated drug resistance can be induced by soluble factors …

Cytotoxic chemotherapeutics primarily function through DNA damage-induced tumor cell
apoptosis, although the inflammation provoked by these agents can stimulate anti-cancer …

It has been recently recognized that the tumor microenvironment (TME) is an essential factor
that defines the efficiency of chemotherapy. The local TME, consisting of immune cells with …

The tumor microenvironment (TME) not only plays a pivotal role during cancer progression
and metastasis but also has profound effects on therapeutic efficacy. In the case of …

Macrophages are essential components of the inflammatory microenvironment of tumors.
Conventional treatment modalities (chemotherapy and radiotherapy), targeted drugs …

Tumorigenesis is not only determined by the intrinsic properties of cancer cells but also by
their interactions with components of the tumor microenvironment (TME). Tumor‐associated …

Immunotherapy is revolutionizing cancer treatment; however, complete responses are
achieved in only a small fraction of patients and tumor types. Thus, there is an urgent need …