Regulatory T cells (Tregs), an essential component of the human immune system, are a
heterogeneous group of T lymphocytes with the ability to suppress immune responses and …

FOXP3 is a transcription factor that is essential for the development of regulatory T cells, a
branch of T cells that suppress excessive inflammation and autoimmunity,,,–. However, the …

Within the three‐dimensional (3D) nuclear space, the genome organizes into a series of
orderly structures that impose important influences on gene regulation. T lymphocytes …

Hepatocellular carcinoma (HCC) is a highly malignant tumor with significant global health
implications. The role of CD4+ T cells, particularly conventional CD4+ T cells (Tconvs), in …

Foxp3-expressing CD4 regulatory T (Treg) cells play a crucial role in suppressing
autoimmunity, tolerating food antigens and commensal microbiota, and maintaining tissue …

Regulatory T-cells (Tregs) play a crucial role in maintaining immune homeostasis, ensuring
a balanced immune response. Tregs primarily operate in an antigen-specific fashion …

Having suffered a DNA breakage, a genomic locus undergoes alterations in 3-D chromatin
architecture to facilitate signaling and repair. While cells possess mechanisms to repair …

The DNA-binding activities of transcription factors (TFs) are influenced by both intrinsic
sequence preferences and extrinsic interactions with cell-specific chromatin landscapes and …

Dosage-sensitive transcription factors (TFs) underlie altered gene regulation in human
developmental disorders, and cell-type specific gene regulation is linked to the …

B-cell acute lymphoblastic leukemia (B-ALL) is the most common pediatric malignancy.
Based on gene expression profiling, B-ALL can be classified into distinct transcriptional …