Pulmonary vascular remodeling is the critical structural alteration and pathological feature in
pulmonary hypertension (PH) and involves changes in the intima, media and adventitia …

Rationale: Glycolytic shift is implicated in the pathogenesis of pulmonary arterial
hypertension (PAH). It remains unknown how glycolysis is increased and how increased …

Impaired mitochondrial fusion, due in part to decreased mitofusin 2 (Mfn2) expression,
contributes to unrestricted cell proliferation and apoptosis‐resistance in hyperproliferative …

Pulmonary arterial hypertension (PAH) is a chronic disease characterized by a progressive
elevation in mean pulmonary arterial pressure. This occurs due to abnormal remodeling of …

Chronic obstructive pulmonary disease (COPD) is a multisystemic respiratory disease that is
associated with progressive airway and pulmonary vascular remodeling due to the …

Acute lung injury (ALI) is characterized by lung vascular endothelial cell (EC) barrier
compromise resulting in increased endothelial permeability and pulmonary edema. The …

Pulmonary artery smooth muscle cell (PASMC) proliferation contributes to pulmonary
vascular remodeling, which ultimately leads to pulmonary arterial hypertension (PAH) …

Endoglin is a membrane glycoprotein primarily expressed by the vascular endothelium and
involved in cardiovascular diseases. Upon the proteolytic processing of the membrane …

Pulmonary arterial hypertension (PAH) is a progressive cardiovascular disease with high
mortality. However, there were no efficient medical drugs for PAH to enormously improve the …

Aims: Airway and pulmonary vascular remodeling is an important pathological feature in the
pathogenesis of chronic obstructive pulmonary disease (COPD). Tobacco smoke (TS) …